SummaryThe problems of haemostasis in haemophiloid patients are considered on the basis of a dynamic equilibrium between fibrin formation and fibrin resolution. It is suggested that the observation by Boudreaux and Frampton of an orally acting haemostatic factor in pea nuts is a result of a delayed fibrin resolution, caused by an antifibrinolytic compound, and not of a restoration of the plasma thromboplastin system (the antihaemophilic factor). This assumption is supported by the results of some preliminary experiments. The haemophiloid disorders represent a deviation in the normal haemostatic balance. For this reason they acquire a broader significance in the study of the physiology and pathology of tissue repair processes than represented by the number of patients carrying these diseases. Some implications concerning the pathogenesis of arteriosclerotic lesions are suggested.
SummaryThe influence of glass contact on the thrombin generation test was demonstrated and a modified method described.Nearly all prothrombin had been converted to thrombin before the thrombin concentration reached its maximum.
SummaryPregnant mice are more susceptible to the intravenous injection of tissue thromboplastin than nonpregnant mice. This was true whether death of the animal, or the appearance of neurological symptoms, was used as indicator of toxicity. Increase of fibrinogen concentration or prior injection of plasmin or of a protease inhibitor (trypsin inhibitor from bovine lung) did not influence the immediate toxic effects. The reason for the increased sensitivity of pregnant mice to tissue thromboplastin remains undisclosed. Inhibition of tissue thromboplastin by serum is a slow process. The reported increase in inhibition of tissue thromboplastin by serum from pregnant individuals could not be confirmed.
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