Exacerbation of chronic obstructive pulmonary disease (COPD) negatively influences on mortality, health related quality of life and lung function decline. Systemic corticosteroids are used to treat acute exacerbations of COPD. Aim. This randomized parallel group study was performed to eval uate short term efficacy and safety of nebulized budesonide (n = 40) and budesonide via a dry powder inhaler (DPI) (n = 40) compared with intra venous (IV) prednisolone (n = 40) in patients with acute non severe COPD exacerbations requiring hospitalization. Methods. The efficacy of treat ment was assessed from the study entry to the Day 10. Clinical improvement was assessed according to an improvement in FEV1, FVC, FEV / FVC, Borg scale, 6 minute walking test (6 MWT), SGRQ C and occurrence of adverse events. Results. Systemic prednisolone, budesonide DPI and neb ulized budesonide improved lung function in patients with acute exacerbation of COPD. Inhaled corticosteroids did not demonstrate systemic activ ity compared to systemic prednisolone. Conclusion. Our study suggests that nebulized budesonide and high dose budesonide DPI could be an alter native treatment to systemic steroids in patients with acute non severe exacerbation of COPD.
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