Acute kidney injury (AKI) is a common and significant medical problem. Despite the kidney’s remarkable regenerative capacity, the mortality rate for the AKI patients is high. Thus, there remains a need to better understand the cellular mechanisms of nephron repair in order to develop new strategies that would enhance the intrinsic ability of kidney tissue to regenerate. Here, using a novel, laser ablation-based, zebrafish model of AKI, we show that collective migration of kidney epithelial cells is a primary early response to acute injury. We also show that cell proliferation is a late response of regenerating kidney epithelia that follows cell migration during kidney repair. We propose a computational model that predicts this temporal relationship and suggests that cell stretch is a mechanical link between migration and proliferation, and present experimental evidence in support of this hypothesis. Overall, this study advances our understanding of kidney repair mechanisms by highlighting a primary role for collective cell migration, laying a foundation for new approaches to treatment of AKI.
The use of "event-based" algorithms for particle transport Monte Carlo methods has allowed the successful adaptation of these methods to vector supercomputers. An alternative algorithm for the specific application of photon transport in an axisymmetric inertially confined fusion plasma has been developed and implemented on a vector supercomputer. The new algorithm is described; its unique features are discussed and compared with existing vectorized algorithms for Monte Carlo. Numerical results are presented illustrating its efficiency on a vector supercomputer, relative to an optimized scalar Monte Carlo algorithm that was developed for this purpose.
I n a Kraft process of pulp and paper production, white liquor containing active chemicals sodium hydroxide, NaOH, and sodium sulfi de, Na2S, are recovered in the sodium loop for re-use, as shown in Figure 1. The wood pulp fi bres go through a bleaching process. The pulp then fl ows through the headbox and is dried to make the fi nal product.In the sodium loop, black liquor is concentrated and burned in the recovery boiler. The resulting smelt is dissolved and reacted with quick lime, CaO, to convert sodium carbonate, Na 2 CO 3 , into NaOH.In the calcium loop of the recovery cycle, lime kilns are used to convert lime mud back to quick lime for re-use in the causticizing process. The rotary lime kiln considered in this work is effectively a direct-contact counter-fl ow heat exchanger. The endothermic reaction that takes place in the lime uses energy from the hot burnt gases that fl ow above the mud.The rotary lime kiln is a long cylinder typically 3 m in diameter and 90 m in length. It rotates about its axis at roughly 1 rpm and is sloped at 2°d. Lime mud is fed from the elevated cold end and moves down the kiln due to rotation and gravity. The retention time for the mud in the kiln is two to three hours. The hot end, in which the burner operates, is typically maintained at about 1200°C by burning fuel (natural gas or oil).Modelling the details of the burner is important. Many problems associated with the kiln operation, such as poor product quality, low fuel effi ciency and short refractory life can be related to the design and operation of the burner.Physical phenomena present in the kiln include: threedimensional turbulent gas fl ow with combustion, threedimensional non-Newtonian fl ow in the lime mud (bed motion), A three-dimensional steady-state model to predict the fl ow and heat transfer in a rotary lime kiln is presented. All important phenomena are considered for the pre-heat and calcination zones including turbulent gas fl ow, buoyancy, all modes of heat transfer, evolution and combustion of species and granular bed motion with calcination reaction. The model is based on a global solution of three sub-models for the hot fl ow, the bed and the rotating wall/refractories. Information exchange between the models results in a fully coupled 3-D solution of a rotating lime kiln. The overall model is validated using UBC's pilot kiln trials (5.5 m laboratory kiln). Results for this case are presented and potential implications are discussed.On présente un modèle tridimensionnel en régime permanent pour prédire l'écoulement et le transfert de chaleur dans un four à chaux rotatif. Tous les phénomènes importants sont considérées pour les zones de pré-chauffe et de calcination, y compris l'écoulement de gaz turbulent, la fl ottabilité, tous les modes de transfert de chaleur, l'évolution et la combustion des espèces et le déplacement de lit granulaire avec la réaction de calcination. Le modèle repose sur une solution globale de trois sous-modèles pour l'écoulement chaud, le lit et les parois rotatives/réfractaires. L...
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