New anthracycline antibiotics 3'-O-demethyl mutactimycin (3) and 4-O, 3'-Odidemethyl mutactimycin (4) were isolated from two actinomycetes strains, Nocardia transvalensis and Streptomyces sp. GW 60/1571. The chemical structures were elucidated by mass spectrometry and NMR spectroscopy. Antibiotic 3 displayed moderate antimicrobial activity against Gram-positive bacteria and cytotoxicity against P388, L1210 Human nocardioses are caused by members of the Nocardia asteroides complex (N. asteroides sensu stricto, N. farcinica and N. nova), N. brasiliensis, N. otitidiscaof the productivity of pathogenic Nocardia strains suggested that bioactive metabolite formation is limited to N. brasiliensis. Recently we investigated a series of Nocardia strains belonging to species other than N. brasiliensis. One of these strains from the National Institute of Health, Nonthaburi (Thailand) identified as N. transvalensis3) was found to produce several antibacterial coloured
Demethyl Mutactimycins, New Anthracycline Antibiotics from Nocardia and Steptomyces Strains. -The isolated title compound (Ia) shows moderate activity against Gram positive bacteria and also cytotoxicity against P388, L1210 and HeLa tumor cells. -(SPEITLING, M.; NATTE-WAN, P.; YAZAWA, K.; MIKAMI, Y.; GRUEN-WOLLNY, I.; RITZAU, M.; LAATSCH, H.; GRAEFE, U.; J. Antibiot. 51 (1998) 8, 693-698; Res. Cent.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.