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The effectiveness of streptomycin on Gram-

Summary A longitudinal study has been conducted on 114 children in a hospital for primary tuberculosis, in order to determine the incidence of Group A latent streptococcal infection. The subjects were regularly examined for the presence of Group A streptococcus in the throat, the level of streptococcal antibodies in the sera; a daily methodical investigation was also performed in the search of any clinical symptoms of infection. The analysis of the modes of infection shows that several degrees exist between the subject remaining free of any contact with group A streptococcus and that one who presents a clinically acute infection; some children are truly healthy carriers, but more frequently the acquisition of the germ is followed by a rise of serological reactions. This infection may be clinically latent, 01: may show Clinical Symptoms of disease. Children classified as chronic carriers may harbour a single type of streptococcus or two or more types which may or may not be present concurrently within the carrier.

The authors report two male cases of liver ornithine carbamyl transferase deficiency. In one the disease occurred at 8 years of age with hyperammoniemic coma leading to death in 48 hours. In the second case, symptoms appeared on the sixth day of life but the outcome was favorable. The child is normal at 15 months. In both cases, there was a residual 6-10% OCT activity. These observations are similar to two other male cases in the literature and are different from the male neonatal fatal form in which the deficiency is virtually total. They underline the genetically heterogeneous nature of OCT deficiencies and the fact that in this X-transmitted trait, hemizygotes can preserve a functional enzymatic activity compatible with life.

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