Ayurvedic system of medicine is one of the oldest systems in India. Herbs and herbal products, with their incredibly wide use throughout time and place, continue to provide real health benefits while maintaining safety profile. The conservative drug available in the marketplace to treat inflammation produces various side effects. To conquer these problems, medicinal plants play a major role to alleviate many diseases related with inflammation and analgesia. Capparis moonii Wight (Family -Capparidaceae) is one of the most famous timber plants in the world and is renowned for its dimensional stability, extreme durability and hard which also resists decay even when unprotected by paints and preservatives. The objective of present study was to evaluate phytochemical screening and in vitro anti-inflammatory activity of ethanolic extracts of Capparis moonii Wight fruit. Capparis moonii Wight fruit shows many activities such as anthelmintic, anti-itching also. The results of plant extract containing various phytochemicals like flavonoids, glycosides, alkaloids which were found to have significant (P < 0.005) in vitro anti-inflammatory activity.