Background: (1) To study FSH, LH and Estrogen levels and it's correlation with Serum Ferritin levels in Female Beta Thalassemia Major patients. (2) To study the correlation of these hormones and SMR with Serum Ferritin. (3) To compare these hormone levels and SMR of Patients with Controls. Study Design: It was a cross-sectional case control study done in a tertiary care centre in a large Metropolitan city over a period of 2 years. Methods: The study was approved by the Institutional ethical committee. The patients attending the Emergency, in-patient and outpatient Departments of Pediatrics Division of our institute were enrolled for the study as per the criteria given. It was a cross-sectional case control study done in patients who had already been diagnosed with beta thalassemia major (cases) and healthy girls (controls). The demographic data, ferritin levels, chelation therapy, SMR staging and hormonal essays of FSH, LH, estrogen and their correlation with blood transfusions and serum ferritin levels was studied. Also the hormone levels and SMR staging of patients with thalassemia major were compared with control group. Results: 56 girls having beta thalassemia major (cases) and 50 healthy girls not suffering from any ailments as (controls) per inclusion and exclusion criterion were enrolled in this study. Estimation of FSH in test and control subjects revealed that The difference was not significant in the age group of 8-12 years (P=0.323). The FSH values of cases >12 years were significantly lower than those of controls (P<0.001). Estimation of oestrogen and LH revealed that these values were significantly lower in Thalassemics as compared to non thalassemics in both age groups (P<0.001). 0% Cases and 26.3% Controls had attained Menarche in the age group of 8-12 years whereas 11.4% Cases and 93.3% Controls in the age group of >12 years had attained Menarche . In our study the mean age of attainment of menarche was 14.5 in thalassemics and 11.5 in non thalassemics. The differece was found to be very highly significant (P<0.001). The association of serum ferritin and FSH, LH and oestrogen levels revealed that a statistically significant association was found in between Sr ferritin and FSH (P=0.015) and oestrogen (0.008). While for LH the difference was insignificant (P=0.174). Association of FSH,LH and oestrogen with duration of chelation therapy showed that there was no significant difference in between FSH,LH and oestrogen levels with respect to duration of chelation therapy. Conclusion: Our study concluded that Delayed growth and Puberty is a common complication of beta thalassemia major. Regular chelation therapy reduces serum ferritin levels and improves FSH, LH and estrogen levels.
International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations. We present a 38-year-old female who presented to our casualty with acute respiratory failure which resolved on high dose corticosteroids. Patient on evaluation was diagnosed to have diffuse alveolar hemorrhage with idiopathic pulmonary hemosiderosis. Patient is currently asymptomatic and is on regular follow-up in our hospital. IJCRI publishes ReviewConclusion: Diffuse alveolar hemorrhage should be a differential diagnosis in a patient presenting with hemoptysis, breathlessness, anemia and radiological evidence of infiltrates. Awaiting detailed work-up, patients should be promptly started on high dose steroids.
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