Introduction: Renal neoplasms are tumors that arise in renal tubular epithelium. These tumors account for about 2% of all cancer deaths. Benign renal neoplasm and tumor like conditions overlap with the malignant tumors. Accurate diagnosis is important for the treatment and prognosis of the patients. Aim: To study histopathology of renal neoplasms and tumor like lesions. To differentiate malignant renal neoplasms from benign and tumor like conditions. Materials and Methods: This retrospective study includes 31 cases admitted in our hospital. Patients who underwent nephrectomy for renal masses were enrolled in the study. Clinical data was obtained, grossing of the nephrectomy specimens and histological examination was done. Immunohistochemistry markers were used wherever necessary. Results: Out of 31 cases studied, 21 were malignant, 3 were benign and 7 were categorized into tumor like conditions. The Panel of IHC markers used in this study were (CD 10, CK 7, CD 117).
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