A series of piperazine (2-chloroethyl)-1-nitrosourea analogues (6a-h) have been designed, synthesized, characterized and screened for
anticancer activity against five human cancer cell lines viz. human colorectal cancer (HCT-116 and HCT-15), human colon cancer (Colo-
205), human breast cancer (MCF-7) and leukaemia (Molt-4). Among the screened compounds, compound 6f exhibits potent activity
against HCT-116 cell line with an IC50 of 1.0 μM, which regarded as promising drug candidate for the development of anticancer agents.
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