The authors present a case of Monilium albicans of the urinary bladder with a review of the pathogenesis and treatment. We consider the bladder infection to be a result of a vulvo-vaginal or anal infection. The lesion may present thrush-like lesions which produce pseudo membranous cystitis, or soft globules – grey or yellow in color, which can be easily voided or aspirated from the bladder. The cystographic appeance is a typical ‘swiss cheese’ shadow which may be falsely interpreted as multiple tumors. The bacteriologist makes the diagnosis by using Sabouraud’s dextrose agar medium. The disease was seen exclusively in diabetics, practically all of them females, 89% of whom had been on antibiotics. The authors conclude that patients with diabetes, recurrent urinary tract infections and persistent vaginal moniliasis should have their urine cultured on Sabouraud’s media. It is much easier to treat the disease in its early phase than later when the Monilium albicans involves the entire wall, or when it fills the bladder with small fungus balls.
I A gas-liquid chromatography procedure for the determination of chlorphentermine (I), N-hydroxychlorphentermine (II) and a,o-dimethyl-a-nitro-,-44-chlorophenyl)ethane (IV) in urine has been developed. Also methods are reported to determine conjugated II and the total N-oxidized metabolites of I, i.e. II, conjugated II, a,a-dimethyl-a-nitroso-3-(4-chlorophenyl)ethane (III) and IV in urine.2 The synthesis of ,ct-dimethyl-a-nitroso-f-(4-chlorophenyl)ethane (III) and its properties are reported. 3 The kinetics of urinary excretion of I and its metabolic products after the oral administration of I to a human subject on separate occasions have been studied. Under normal conditions of urinary pH, metabolism by N-oxidation was the main elimination route of I; acidifying the urine increased the urinary excretion of unchanged I at the expense of the N-oxidized products. 4 The importance of the N-oxidation metabolic route in the distribution of chlorphentermine (I) in man is discussed.
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