A novel strain of coronavirus, namely, SARS-CoV-2 has already taken the lives of more than 2 million people worldwide, causing several socio-economic and political disturbances, affecting our daily life. There are no definite therapies available and research is still being conducted to identify and develop an effective antiviral drug leads against SARS-CoV-2. Therefore, there is an immediate need to identify and develop new or repurposed antiviral (anti-coronavirus) drug leads. The virus requires the main protease (Pdb ID:6WTT), a multifunctional protein involved in the processing and replication of the viral RNAs. This paper aims to screen potential phytochemical compounds of Coriandrum sativum against the viral main protease. In order to identify a novel potent inhibitor, we have performed docking studies on the SARS-CoV-2 main protease with the phytochemical compounds of Coriandrum sativum. Among studied compounds, Cosomosiin, Erucic acid, Rosemarinic, and Pimentel appear to be potential inhibitors of the SARS-CoV-2 main protease. When docked against the crystal structure of the main protease, these four compounds revealed Libdock scores of 141.40, 133.89, 143.89, and 148.60 respectively. However, all these identified phytochemical compounds need to be further validated by molecular dynamics and invitro lab experiments for clinical use only after appropriate trials.
Background: Obesity and overweight are widespread phenomena. Dyslipidaemia observed in obese people is an important risk factor for coronary heart disease. Levels of obesity have been shown to be associated with low-grade inflammation and C-reactive protein, an inflammatory marker has been associated with the presence and severity of atherosclerosis. Aims & Objective: To evaluate the Hs-CRP levels in overweight individuals with dyslipidaemia and without dyslipidaemia, and thus assess its role in detecting cardiovascular disease (CVD) in overweight individuals. Material and Methods: 120 overweight subjects were included in the study, they were divided into 2 groups-Group I which included subjects with dyslipidaemia and Group II included normolipemic subjects. BMI, Hs-CRP, Total Cholesterol, HDL
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