BACKGROUNDAllergic rhinitis is rather erroneously viewed as a trivial disease, it is important to note that it can significantly affect the quality of life. There is significant overlap between bronchial asthma and allergic rhinitis. AIMSThis study was done to assess the prevalence of asthmatics in allergic rhinitis patients. MATERIALS AND METHODSA community based cross sectional study was conducted in Bangalore, among 1000 adults aged 30 yrs and above. Allergic rhinitis was diagnosed as per ARIA guidelines. Sperometery was done to diagnose asthma among them. Multivariate logistic regression analysis has been used to find the association of risk factors with disease. RESULTSAmong subjects with allergic rhinitis, 40(33%) were also diagnosed to be suffering from concomitant asthma showing a considerable overlap between rhinitis and asthma. CONCLUSIONBurden of allergic rhinitis is high with a considerable overlap with asthma. This highlights the importance of early and regular treatment.
Background:This open-labeled, post-marketing study was conducted to assess the efficacy and tolerability of fixed dose combination of amlodipine and metoprolol extended release capsules in mild to moderate hypertension in adult Indian patients.Materials and Methods:Of 101 enrolled patients, 64 drug naïve patients were treated with regimen A (amlodipine 5 mg + metoprolol 25 mg) and those with prior history of hypertension (n = 37) were treated with regimen B (amlodipine 5 mg + metoprolol 50 mg) for 8 weeks. Treatment response was assessed at week 4 and 8. Dose up titration to regimen B was carried out for those who failed to achieve the target blood pressure (BP) at week 4 in regimen A and additional antihypertensives were added to those in regimen B. Safety laboratory tests were performed at baseline and end of study.Results:Mean age (±SD) of patients was 53.36 (±11.26) years and body weight (±SD) 63.40 (10.03) kg. Ninety five patients (94.06%) were only hypertensive and 6 (5.94%) had hypertension with history of coronary artery disease; mean duration (±SD) of hypertension was 42.50 (48.07) months. At baseline, patients had a mean (±SD) systolic blood pressure (SBP) and diastolic blood pressure (DBP) of 154.98 (±7.76) mmHg and 95.55 (±5.70) mmHg respectively. There was a statistically significant (P < 0.001) reduction of 12.16% and 14.69% in SBP, 11.49% and 14.65% in DBP at week 4 and week 8 respectively, compared to baseline. Normalization of overall BP was achieved in 49.49% and 70.71% patients at week 4 and 8, respectively. Peripheral edema was reported in 2.97% (3/101) patients.Conclusion:This combination was safe, efficacious, and well-tolerated in study population.
BACKGROUND TB is a major health issue worldwide. Regular treatment is essential to halt the transmission of the infectious agent. Recognising the problems of TB patients and effective measures to resolve them is critical for the success of RNTCP. AIM To assess the education demography, socioeconomic factors influencing compliance of TB patients to DOTS therapy. MATERIAL AND METHODS Cross-sectional observational study was conducted to obtain the information regarding the missed doses and was verified from the treatment card of the patients. Chia square test was used to access the results. RESULTS TB was found to be affecting common people in age group 15 to 35 (71%) lower middle to lower class, low literacy levels and overcrowded conditions. Factors significantly associated with missed doses were low level of education, unemployment, unmarried and divorced individuals and nuclear families. CONCLUSION Education, occupation and socioeconomic status are interrelated factors that have immense influence on the compliance to DOTS.
BACKGROUNDMigraine is a common neurological problem accounting for large morbidity and disability. Ergotamine and triptans are mainly used to terminate the attack of severe migraine. To study the clinical comparison between sumatriptan and ergotamine in migraine patients.
Objectives: The study was aimed to evaluate and analyse the drug promotional literature distributed by pharmaceutical companies to physicians. This was done using World Health Organization (WHO) criteria for ethical medicinal drug promotion and International Federation of Pharmaceutical Manufacturers & Associations (IFPMA) Code of Practice, 2012. Detailed analysis of claims was done. Material and Method: An observational cross-sectional study was carried out in OPD of a tertiary care hospital. A total of 194 brochures were collected and evaluated according to the WHO criteria and IFPMA Code of practice, 2012. Further claims were categorised and detailed analysis of exaggerated and false claims was done and the authenticity of the brochures was checked. Results: None of the brochures gave complete information in accordance to the WHO and IFPMA Code of practice, 2012. Majority of the claims were about efficacy (77.31%) and safety (13.91%). Seven of them were exaggerated and false. Conclusion: The study concluded that the drug information provided in the promotional brochures can be incomplete and unreliable with the questionable credibility. Hence a physician should not rely solely on the brochures. They must undergo a strict process of assessment regarding information provided, especially related to efficacy and safety.
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