To investigate the influence of silicon and phosphorus application on yield and nutrient content of wheat, a field experiment was carried out at Agronomy Instructional Farm, Chimanbhai Patel College of Agriculture, Sardarkrushinagar Dantiwada Agricultural University, Sardarkrushinagar during Rabi season of 2020-2021. Experimental soil was loamy sand in texture with pH 7.01 and electrical conductivity 0.19 dSm-1. The soil was low in organic carbon (0.39%) and medium in available phosphorus (38.10 kg ha-1) and potassium (191.25 kg ha-1). Available silicon in soils was 60.75 mg kg-1. The experiment was dispersed as four levels of phosphorus (0, 30, 60 and 90 kg P2O5 ha-1) and four levels of silicon (0, 100, 200 and 300 kg Si ha-1) laid in randomized block design with factorial concept and replicated thrice. All the plots received a uniform recommended dose of nitrogen at 120 kg ha-1. Yield and nutrient content viz., nitrogen, phosphorus, potassium and silicon of grain and straw were noted. The results of experiment clearly indicated that the individual application of 60 kg ha-1 phosphorus and 100 kg ha-1 silicon recorded the significantly highest grain yield of 3808 and 3619 kg ha-1, respectively. With respect to phosphorus and silicon content in grain (0.36 and 1.64%) and straw ( 0.32 and 1.67%), individual application 60 and 90 kg P2O5 ha-1 and 100 kg Si ha-1 and 300 kg Si ha-1recorded maximum, respectively. As of interaction effect, significantly highest grain yield (4304 kg ha-1), and phosphorus content in grain (0.39%) was found with interaction effect of 60 kg P2O5 ha-1 with Si level at 100 kg ha-1. Whereas the significantly highest straw yield (6201 kg ha-1), silicon content in grain (1.82%) and straw (4.21%) was found with interaction of 90 kg P2O5 ha-1 with Si level at 100 kg ha-1and 90 kg P2O5 ha-1 with Si level at 200 kg ha-1. From the results of experimentation, it is clear that application of 60 kg P2O5 ha-1 along with 100 kg Si ha-1 could be better for increasing yield and nutrient content in wheat in loamy sand soils under North Gujarat Agro-climatic conditions.