There was no significant difference in biomechanical properties between the RoSA/TSP and the PFNA for the fracture pattern tested. However, failure modes differed between the 2 implants with greater femoral neck shortening observed in the RoSA/TSP group.
Objective
Sepsis, a leading cause of mortality in critically ill patients, is closely linked to the excessive activation of coagulation and inflammation. Protein Z (PZ), a cofactor for the protein Z-dependent protease inhibitor (ZPI), enhances the inhibition of coagulation factor Xa and ZPI inhibits factor XIa in a PZ-independent fashion. The functions of PZ and ZPI in the inflammatory and coagulant responses to septic illness have not been evaluated.
Design
For induction of generalized Shwartzman reaction (GSR), dorsal skinfold chamber-equipped mice were challenged twice with lipopolysaccharide (0.05 mg/kg bw on day −1 and 5 mg/kg bw 24 h later). Time-matched control animals received equal volumes of saline.
Setting
University research laboratory.
Subjects, Interventions and Measurements
Using intravital fluorescence microscopy in ZPI-deficient (ZPI−/−) and PZ-deficient (PZ−/−) mice as well as their wild-type littermates (ZPI+/+, PZ+/+), kinetics of light/dye-induced thrombus formation and microhemodynamics were assessed in randomly chosen venules. Plasma concentrations of CXCL1, IL-6 and IL-10 were measured. Liver and lung were harvested for quantitative analysis of leukocytic tissue infiltration and thrombus formation.
Main Results
After induction of GSR, all mice showed significant impairment of microhemodynamics, including blood flow velocity, volumetric blood flow and functional capillary density as well as leukocytopenia and thrombocytopenia. Thrombus formation time was markedly prolonged after induction of GSR in all mice, except of ZPI−/− mice, which also had a significantly higher fraction of occluded vessels in liver sections. PZ−/− mice developed the highest concentrations of IL-6 and IL-10 in response to GSR and showed greater leukocytic tissue infiltration than their wild-type littermates.
Conclusions
In this murine model of GSR, ZPI deficiency enhanced the thrombotic response to vascular injury, whereas PZ deficiency increased inflammatory response.
Pengabdian masyarakat ini bertujuan untuk pengabdian masyarakat ini adalah untuk memperkuat strategi bisnis para pelaku UMKM, khususnya strategi di bidang pemasaran. Dalam pengabdian ini, yang menjadi mitra adalah para pelaku UMKM yang menjadi anggota Koperasi Setia Bhakti Wanita Surabaya. Kegiatan ini dilaksanakan pada hari Senin, 28 November 2016. Para peserta yang hadir sangat antusias mengikuti setiap sesi pemaparan materi dan termotivasi untuk mengajukan pertanyaan-pertanyaan
This study aims to test and analyze the factors that account for the success of women MSME efforts in Surabaya This type of research used is causal research. The sample from this study numbered 84 people using purposive sampling techniques. The data analysis technique used is a multiple regression analysis technique with the SPSS 16.0 program. The results of hypothesis testing showed that the entrepreneurial spirit had no significant positive effect on business success, motivation had a significant positive effect on business success, entrepreneurial competence had a significant positive effect on business success, creativity had a significant positive effect on the success of women's MSME businesses in Surabaya. The implications in this study are that motivation, entrepreneurial competence and creativity have an important role in the success of women’s MSME businesses in Surabaya. Female MSME owners in Surabaya need to increase the spirit of entrepreneurship, increase knowledge and skills to manage the business, be creative about the products offered and creative marketing system because this is able to increase business success.
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