pembrolizumab) were reviewed nearly twice as frequently (35.8%) as TKIs (16.7%). All immunotherapies, except durvalumab, were evaluated by all studied countries, with a majority of decisions published as favorable (58.1%). High cost of immunotherapies was commonly cited as the reason for unfavorable decisions, while increased evidence for clinical benefit in patient subpopulations was often requested for mixed and neutral decisions. Conclusions: More than half of all HTA decisions were categorized as favorable. Immunotherapies were among the most commonly evaluated NSCLC treatments. Further emphasis on developing and evaluating robust health economic and clinical data is necessary as the landscape shifts towards precision medicine.
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