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The objectives of the present study were to evaluate the efficacy of intra-mammary-administered cefquinome for the treatment of sub-clinical mastitis in lactating dairy cows and to determine if extended therapy would enhance treatment efficacy. Seventy-three Holstein dairy cows from a single farm with 150 infected quarters were enrolled in the study. Infected cows were allocated randomly to one of three treatment regimens: (1) conventional (standard) regimen: 75 mg of cefquinome administered three times at 16-h intervals (25 infected cows, 52 intra-mammary infections (IMI)), (2) extended regimen: 75 mg of cefquinome administered six times at 16-h intervals (26 infected cows, 58 IMI) and (3) negative untreated control group (22 cows, 40 IMI). Most IMI were caused by coagulase-negative staphylococci, streptococci other than Streptococcus agalactiae and coliforms. The overall bacteriological cure (BC) rates for sub-clinical IMI were 84.61%, 91.37% and 20% for the conventional, extended and the control groups, respectively, indicating a higher BC rate for the treated groups than the control group (P < 0.001). Significant differences in somatic cell count (SCC) were detected between the treated versus the control group (P < 0.001). No differences, concerning the BC rate or SCC, were observed between the extended and the conventional groups. Although fat and protein percentages increased in the treated groups, there were no significant differences in post-treatment milk production between the groups. Results of this study indicate that cefquinome therapy was effective in reducing SCC and eliminating sub-clinical IMI in lactating dairy cows, but extended therapy did not enhance treatment efficacy.

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Endoscopic, cytologic, bacteriologic and histologic examinations of the endometrium were performed on 34 subfertile Turkaman cross-bred mares to evaluate the significance of the hysteroscopic method and biopsy as a gyneacological evaluation. Fifty percent of the mares showed pathological changes on endoscopy, including adhesions, fluid accumulation, endometrial cysts and atrophy of the endometrial folds. Three, 23 and 8 cases classified as grades II A, II B and III, respectively, in biopsy samples base on the Kenney and Doig classification [11]. Multiple endometrial cysts occurred in 12 mares (35.3%) and 2 of them were younger than 10 years. Most of the large lymphatic cysts were situated near the bifurcation of the uterine body. Adhesions were found only in one mare. Only 4 of the 17 cases in which endometritis was clearly diagnosed were identified by endoscopy, but none of the endometrial cysts or intraluminal adhesions which were identified by endoscopy were determined by uterine biopsy, cytology and culture. In view of the results of this experiment, it can be concluded that in diagnosing endometritis, biopsy, cytology and culture of the endometrium is more diagnostic than endoscopy, but in differentiating gross pathological changes in the uterus such as intrauterine adhesions and endometrial cysts, endoscopy is more efficient.

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Environmental and minor pathogens seem to be of increasing significance, especially in situations where major contagious pathogens (Streptococcus agalactiae and Staphylococcus aureus) have been controlled using post-milking teat disinfection and dry cow therapy. Herd management practices that successfully control contagious pathogens fail to control coliforms and many streptococcal bacteria. Coagulase-negative staphylococci (CNS) are the most prevalent bacteria isolated in herds using currently recommended control measures and Corynebacterium bovis ( C. bovis) was identified as the cause of up to 20% of all cases of clinical mastitis in some herds.