1972). Brit. J. industr. Med., 29,[298][299][300][301][302][303][304][305][306]. Acute effects of exposure to orthochlorobenzylidene malononitrile (CS) and the development of tolerance. Of the many compounds capable of producing irritation of the eyes and upper respiratory tract two, co-chloroacetophenone and orthochlorobenzylidene malononitrile (CS), have been used as riot control agents. The latter, CS, has been in use for more than 10 years and is currently still in service. When dispersed as a smoke consisting of 1-micron diameter particles CS will produce lachrymation and pain and discomfort in the upper respiratory tract and chest. Exposed individuals become apprehensive and highly motivated to escape from the smoke. Recovery from these effects occurs within minutes of the affected individual reaching fresh air.The present study reports the effects produced by CS aerosol on 35 healthy male volunteers who were exposed in such a way that the total dose of the agent received by each man was greater than that which he might have received in an actual riot; this was achieved by taking advantage of the fact that adaptation to the effects of CS occurs if exposure is gradual and to low concentrations. In addition to the clinical observations, cardiological, respiratory, and biochemical observations were made. No abnormalities were observed in the electrocardiogram, respiratory function tests or the blood biochemistry and cell constitution. Such changes that were observed could be ascribed to the emotional stress and discomfort of the experiment.Many compounds, when disseminated as vapour or aerosol, are capable of producing, in man, irritation of the eyes and upper respiratory tract; two in particular, co-chloroacetophenone (CN) and 0-chlorobenzylidene malononitrile (CS), are highly potent and specific in producing these effects and for this reason have been utilized as the active ingredient of tear smoke.
Thirty‐six alkyl organophosphorus compounds have been tested for neurotoxicity in the chicken. The individual compounds were chosen to enable the importance of each portion of the molecule to be assessed in relation to the property of neurotoxicity. Seventeen substances were found to be neurotoxic, fifteen for the first time. All of these contained fluorine. On the basis of the results reported, certain predictions have been made about the chemical structure of compounds which would be expected to be neurotoxic. The importance of fluorine suggests that it plays a direct role in the development of the biochemical lesion, and this may occur as the result of its being carried by the molecule as a whole to specific areas in the nervous system. By the action of cholinesterase, the P‐F bond may be ruptured and ionic fluorine liberated where it blocks some metabolic cycle.
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