Altered metabolic parameters in association with antipsychotic medication use in diabetes Wake, D. J.; Broughton, P.; Perera, S. M.; MacIntyre, D. J.; Leese, G. P.
Published in: Psychoneuroendocrinology
DOI:10.1016/j.psyneuen.2016.01.022
Publication date: 2016
Document Version Peer reviewed version Link to publication in Discovery Research PortalCitation for published version (APA): Wake, D. J., Broughton, P., Perera, S. M., MacIntyre, D. J., & Leese, G. P. (2016). Altered metabolic parameters in association with antipsychotic medication use in diabetes: A population based case-control study. Psychoneuroendocrinology, 66, 214-220. https://doi.org/10.1016/j.psyneuen.2016.01.022
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ABSTRACT AimsThis study assess differences in clinical variables in diabetes patients prescribed antipsychotic medication and determines relative schizophrenia prevalence in the diabetes population.
MethodsThis population-based case-control study utilising Scotland's national diabetes registry (SCIdiabetes) and linked psychiatric hospital discharge data (SMR04) established diabetes phenotypes in a patient cohort prescribed long term antipsychotic medication (n=2362)(cases). Cases were matched 1:10 to diabetes patients not prescribed antipsychotic medication (controls) for BMI, gender; diabetes type; birth year; diagnosis date; smoking status. Sub-groups with defined schizophrenia (n=196) or bipolar disorder (n= 190) were further examined. Schizophrenia prevalence in the diabetes versus general population was compared.
ResultsDuring follow up, antipsychotic prescription was associated with lower HbA1c (55.1 (95% CI 54.5-55.8) or 7.2 (95% CI 7.1-7.3)% vs 58.2 (58.0-58.4) mmol or 7.5 (95% CI 7.5-7.5)% p<0.001) lower serum total cholesterol, 4.2 (4.1-4.2) vs 4.3 (4.2-4.3) mmol/ l, p<0.001), lower blood pressure (systolic 130 (130.17-131.29) vs 134 (134.3-134.7) mmHg, p<0.001), higher prescription of oral hypoglycaemic medication (42% (40-45) vs 38% (37-39) p<0.001), similar statin prescriptions (85% (81-89) vs 85% (84-86), p=.55), and lower retinopathy rates (28% (25.6-30.5) vs 32% (31.5-33.1), p<0.001). HbA1c at diagnosis was similar (p=.27).Schizophrenia prevalence was higher in the diabetes versus gene...
