Previous examples of a very weak form of the antigen A have been described by Weiner, Sanger and Race (1959) and by Moore, Newstead and Johnson (1961). These phenotypes did not fit the categories of A, (Race, 1957), A,,, (Weiner et al. 1957), or A,, and were left unnamed for future christening. A second family in which a similar phenotype is inheritedapparently as a dominant effectis reported here. ResultsThe family tree is shown in figure 1. L. R. (11-3), the propositus is a healthy blood donor who has never had a transfusion. His sister (11-2) and one son (111-1) have an A antigen with similar characteristics. The other members of the family have blood groups with normal serological properties.(1) Agglutination Tests. (a) The anti-A and anti-A+B sera from stimulated donors that were used to test the cells of J. A. [l] were also
Summary A weak form of the antigen A is reported in a healthy adult. It does not appear to correspond with any other weak form of A previously reported, except perhaps with that of Weiner, Race and Sanger. Centrifugation methods with antisera from donors injected with group specific substances are essential for the reliable demonstration of this antigen which, under these circumstances, gives a typical microscopic picture of isolated small clumps of cells set in a sea of unagglutinated cells. No symbol is used to designate this phenotype as its position within the ABO system is not clear. Résumé Les auteurs décrivent un antigène A faible chez un adulte en bonne santé. Il ne semble pas correspondre aux autres formes de A faibles déjà décrites sinon à celles de Weiner, Race et Sanger. Les méthodes de centrifugation avec des antisérums provenant de donneurs immunisés avec des substances de groupes spécifiques sont indispensables pour la mise en évidence de cet antigène qui, dans ces conditions, donne l'image microscopique typique de quelques petites agglutinations érythrocytaires isolées parmi un grand nombre d'érythrocytes non agglutinés. Il n'y a pas de symbole pour désigner ce phénotype et sa position dans le système ABO est peu claire. Zusammenfassung Bei einem gesunden Erwachsenen wurde eine schwache A‐Eigen‐schaft gefunden, welche, mit Ausnahme derjenigen von Weiner, Race und Sanger, mit keiner bisher beschriebenen schwachen A‐Variante übereinstimmt. Der Nachweis erfolgt am besten mit einer Zentrifugiertechnik unter Verwendung von Antiseren von Spendern, welche mit gruppenspezifischen Substanzen immunisiert worden sind. Mit dieser Technik ergibt sich ein charakteristisches Agglutinationsbild mit isolierten kleinen Agglutinaten in einem See von unagglutinierten Zellen. Da die Stellung dieses Antigens im ABO‐Blutgruppensystem noch unklar ist, wurde verzichtet, diesen Phänotyp mit einem neuen Symbol zu bezeichnen.
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