SummaryIn the first part of this study the availability of folinic acid (FA) and its main active circulating metabolite, 5-methyltetrahydrofolate (5-MTHF), were studied in plasma and cerebrospinal fluid (CSF) from normal subjects after i.v. administration of 100 and 250mg of FA. 5-MTHF rapidly appeared in plasma, the maximum value being reached at the first observation time point (1 h
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