In some cases of sudden infant death syndrome (SIDS) the intestinal flora was found to be dominated by Candida albicans. Microbiologic investigations of the various organs showed the occasional presence of different Candida species, but not in the form of massive growth as in sepsis. There is no basis to assume that the activity of yeasts, first of all of Candida albicans, is a contributory factor in the occurrence of SIDS. Candida albicans was shown to produce alcohol from glucose at a rate of maximally 1 mg of alcohol per gram of intestinal content per hour. It is concluded that the intestinal production of alcohol in vivo from cases showing a Candida albicans dominated intestinal flora will not be able to surpass the normal alcohol metabolizing capacity of the liver. Thus, measurable concentrations of alcohol in the blood from such cases cannot be expected.

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Summary. The concentration and distribution of phenothiazine drugs in the body fluids and tissues of 66 autopsy eases are reported. The cases are presented in three groups: (i) those in which poisoning by a phenothiazine drug was the sole cause of death, (ii) cases with "mixed poisoning" by phenothiazine derivatives and other drugs or ethanol, and (iii) instances of death by physical means where phenothiazine drugs were found but had not directly caused death.From the data presented it seems that the level of this kind of drugs in the liver can be of value for evaluting the severity of intoxication. The blood values often reflect levels after the maximum concentration has been passed. Kidney contains varying concentrations without significant trends. The drug concentrations in the urine are not directly related to the severity of the poisoning.A description of the analytical technique used by us is included. Key-Words: Phenothiazine d r u g s -I n t o x i c a t i o n -Poisoning. Zusammen/assung. Die Konzentration und Verteilung yon Phenothiazinderivaten inKSrperflfissigkeiten und Organen yon 66 Sektionsfi~llen werden in 3 Tabellen wiedergegeben (Tabelle 4--6). Sic umfassen 14 FKlle in welehen es sich um reine Phenothiazinvergiftungen handelte, 34 Beispiele yon Vergiftungen mit mehreren Agentien und endlich 18 Todesf~lle aus kOrperlicher Ursaehe, wo aber auch Phenothiazine gefunden wurden. Die aus unserem Sektionsmaterial erhaltenen Ergebnisse werden mit Angaben aus der Literatur verglichen. Diese beziehen sich einerseits auf Todesf/~lle, andererseits auf Serumspiegel nach therapeutischen Gaben yon Chlorpromazin und Thioridazin.Ffir eine Beurteilung tSdlicher Vergiftungen mit dieser Gruppe yon Arzneimitteln scheint der Giftgehalt der Leber am besten geeignet zu sein. :Die zum Zeitpunkt der Sektion beobachteten Serumspiegel sind wahrscheinlieh Werte, die einige Zeit nach t)berschreiten des Konzentrationsmaximums auftreten. Weder die Nieren noch der Ham enthalten Mengen der Arzneimittel (und deren !Vfetaboliten) die in einem gesetzm~Bigen Zusammenhang mit der Schwere der Vergiftung stehen.Die Arbeit enth/£1t schlie$1ich kurze Angaben fiber die yon uns verwendete analytisehe Methodik. Auf den Metabolismus der Phenothiazinderivate wird hier nicht n/iher eingegangen.Toxicological data on lethal poisonings of h u m a n s by phenothiazine drugs are scarce. Since the t o x i c i t y of e.g. chlorpromazine in rats, mice and guinea pigs is comparable to t h a t of certain barbiturates [1], one could expect a high incidence of suicides by the phenothiazine t y p e of drugs. These compounds are

Massive doses of vitamin‐D in a few days provoke heavy clinical symptoms and histologically significant vascular changes, particularly in the aorta, coronary arteries and renal vessels of rats. Intravenous administration of zymosan completely cuts out these effects. Our conclusion is, therefore, that inactivation of circulating complement inhibits the vitamin‐D produced arterial lesions. We suggest that complement not only is an important factor in arteriosclerosis produced by vitamin‐D poisoning, but find it conceivable that it may play a similar key role in human aortic and coronary sclerosis.