No abstract

We report the neonatal courses, early postnatal development, and neuroimaging findings of 17 patients with marked microcephaly and simplified cerebral gyral patterns, a condition that we call microlissencephaly. Retrospective analyses of the clinicoradiologic features of these patients allowed segregation of the patients into 5 distinct groups with varying outcomes. The apparent discreteness of these groups suggests multiple etiologies of this malformation, although there appears to be a strong genetic component with probable autosomal recessive inheritance. Utilizing the neonatal course and neuroradiologic features of these infants allows classification of specific subsets, which may be useful to predict outcome.

At Kamoto and in other Katangan deposits, copper and cobalt occur as sulfides (mostly digenite, chalcocite, bornite and carrollite) in two stratiform orebodies. The host rock is dolostone, chert and shale. There is no metamorphism. Mineralization was emplaced before major tectonic deformation.The two stratiform orebodies are separated by a barren interval. The lower one rests a few feet above an erosional surface which developed over consolidated red dolostone beds completely devoid of sulfides. Above the upper orebody, a sulfide fraction is present, consisting mostly of pyrite with some chalcopyrite.The mineralized sedimentary rocks present some of the features commonly observed in tidal-flat sediments. However, they have undergone a complex sequence of diagenetic transformations. Several authigenic (or partly authigenic) minerals have crystallized: dolomite, perhaps in part from hydromagnesite + CaC03; magnesite, from the remaining hydromagnesite; quartz; chlorite and other phyllosilicates; colorless tourmaline; pyrite; other sulfides: chalcopyrite, bornite, digenite, chalcocite, carrollite, etc ... New evidence is presented to show that this diagenesis took place at first in an environment devoid of copper and cobalt and then proceeded while the metals were brought in from an outside source.The features described may have resulted from a reaction between a hypersaline brine (with high pH and high Eh) flowing through the lower part of the Kamoto Dolostone, and a modified connate water (reducing and less alkaline because of abundant organic matter) present in the upper part.

Six Holstein (light-muscled type) and six Belgian Blue bulls (double-muscled type) were fed a finishing diet. Average daily gain was 1.36 kg for the Holstein bulls vs 1.24 kg for the Belgian Blue bulls (P less than .05). Holstein bulls consumed more feed (2.3 vs 1.8 kg/100 kg body weight, P less than .001) than the Belgian Blue bulls. The dressing percentage (55.4 vs 65.8%, P less than .001) and the proportion of muscle (56.1 vs 71.3%, P less than .001) in the carcass were less, whereas the proportions of adipose tissue (28.3 vs 15.4%, P less than .001) and bone (15.7 vs 13.4%, P less than .05) were higher in the Holstein bulls. Plasma creatinine determined in samples obtained once a week was lower (11.0 vs 20.3 mg/liter, P less than .001) in the Holstein bulls. In contrast, Holstein bulls tended to produce more triiodothyronine (2.3 vs 1.8 nM, P less than .10), tetraiodothyronine (71.9 vs 54.7 nM, P less than .10) and insulin-like growth factor I (IGF-I; 340 vs 205 ng/ml, P less than .20) than the Belgian Blue bulls. Growth hormone, insulin, IGF-I and testosterone were measured at 20-min intervals during two 24-h periods. In wk 6, Holstein bulls tended to produce more growth hormone than the Belgian Blues, as indicated by higher total peak area (3,185 vs 2,431 ng), peak amplitude (34.1 vs 22.6 ng/ml, P less than .10) and baseline (4.6 vs 3.3 ng/ml, P less than .20). In wk 27, the trends were opposite.(ABSTRACT TRUNCATED AT 250 WORDS)