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Various combinations of the prostaglandins synthetase inhibitors, aspirin or indomethacin, and Corynebacterium parvum were used as adjunctive therapy to surgery in the treatment of the metastasizing Dunn osteosarcoma C3H/HeJ mice. In doses corresponding to those that could be tolerated by humans all three agents given singly reduced the number and estimated weight of metastases whether they were administered pre-operatively or post-operatively. When the two modalities of therapy were combined a significant additive anti-tumour effect was observed with both C. parvum and aspirin and C. parvum and indomethacin, but only if treatment was commenced pre-operatively. Similar results were obtained with two other metastasizing turnouts, viz. the B16 melanoma and the Lewis lung carcinoma. In the absence of any evidence for an interaction between the prostaglandin synthetase inhibitors and circulating tumour cells, it was felt that the additive effect could be best explained in terms of interference with prostaglandin-mediated negative feedback of the anti-tumour action of C. parvum. C. parvum 0.025 mg Aspirin 100 mg/kg b.d. C. parvum + aspann C. parvum 0.1 mg Aspirin 100 mg/kg b.d. C. parvum + aspirin C. parvum 0.025 mg Aspirin 100 mg/kg b.d. C. parvum + aspinn C. parvum 0.1 mg Aspirin 100 mg/kg b.d. C. parvum + aspmn C. parvum 0.025 mg Aspirin 100 mg/kg b.d. C. parvum + aspinn C. parvum 0.025 mg Aspirin 100 mg/kg b.d. C. parvum + aspmn

No abstract