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A field experiment was conducted in the sandy loam soils of the Onattukara tract of kerala with rice variety Mahsuri to determine the effect of different levles of fertilisers on the yield and uptake of major nutrients at different stages of crop growth. The results revealed that the uptake of N. P and K increased with increased levels of fertilisers at all the growth stages. The uptake of N and P increased from tillering to flowering and thereafter declined. The uptake of K was at its highest at harvest. The grain and straw yields were also significantly increased by increasing the fertiliser levels, and were found to be siginificantly and positively correlated with the uptake of N, P and K.