Pentraxin 3, a novel inflammatory marker, was more tightly associated with the complexity and severity of CAD than hs-CRP and was found to be an independent predictor for high SYNTAX score.
High NGAL levels may be associated with poor prognosis after PCI in patients with STEMI. However, further studies with larger numbers of patients and longer follow-up are required to evaluate the usefulness of plasma NGAL level for predicting prognosis of STEMI.
Turkey e relation of fragmented QRS with tissue Doppler derived parameters in patients with b-thalassaemia major
AbstractPurpose: e most important complication encountered in patients with b-thalassaemia major is degenerative brosis developing as a result of iron accumulation in myocardial tissue. Dysfunction pursues this accumulation. Recently, presence of fragmented QRS (fQRS) in ECG has been regarded as a predictor of myocardial brosis. We aimed in our study to investigate the frequency with which fQRS develops in patients with bthalassaemia major and to disclose the correlation between fQRS frequency and Dopplerderived indices.Methods: e patients with b-thalassaemia major (n=66; mean age: 23±6 years) and healthy controls (n=30; mean age: 23±4 years) were included. fQRS pattern was described as presence of RSR' manifested as existence of additional R wave and notching in either R or S waves in ECG recordings. 2D, M-mode, conventional Doppler, tissue Doppler echocardiography parameters were assessed. Mean serum ferritin levels over past 5 years were also calculated.Results: When compared to those in control group, fQRS was more frequent in bthalassaemia major group, indicating statistical signi cance (p = 0.001). While E/Em and ferritin level exhibited statistically signi cant increase in thalassaemia patients with fQRS (p < 0.05), the mean Em and Sm values were found to be signi cantly low (p < 0.05).Conclusions: fQRS was frequently observed in the patients with b-thalassaemia major, which was of statistical signi cance. Tissue Doppler-derived diastolic and systolic indices in thalassaemia cases with fQRS showed statistically signi cant impairment compared to those without fQRS. In conclusion, fQRS may represent a novel noninvasive marker for cardiac involvement in patients with b-thalassaemia major. e most important complication in patients with bthalassaemia major is cardiac dysfunction due to accumulation of iron in myocardial cells [1]. Heart failure holds the topmost position among the mortality reasons in patients with bthalassaemia major [2]. 50% of the cases with thalassaemia major are complicated with manifest heart failure, for which reason early diagnosis may prove helpful in the treatment [3,4].Recently, existence of fragmented QRS (fQRS) in ECG strips has been regarded as a predictor of myocardial brosis [5]. at fQRS proved to be a novel marker pointing out possible existence of myocardial scar was documented in the patients with coronary arterial disease [6].Various number of parameters related to conventional Doppler echocardiography was used during investigations on the cardiac functioning in the patients with b-thalassaemia until now [7]. We used in our study the tissue Doppler imaging modality which has less technical limitations compared to conventional Doppler echocardiography.What we aimed in this study was to disclose relationship between tissue Doppler echocardiography-derived indices and frequency of fQRS, a possibly novel indicator that may be used in the early identi cation of cardia...
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