Serum Pentraxin 3 Levels are Associated with the Complexity and Severity of Coronary Artery Disease in Patients with Stable Angina Pectoris

Karakaş, Mehmet; Büyükkaya, Eyüp; Kurt, Mustafa; Motor, Sedat; Akçay, Adnan Burak; Büyükkaya, Şule; Karakaş, Esra; Bilen, P.; Şen, Nihat

doi:10.2310/jim.0b013e31827c2971

Cited by 38 publications

(32 citation statements)

References 36 publications

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“…Plasma PTX3 is more closely associated with the angiographic complexity and severity of CAD than is CRP [34]. Furthermore, we found that the prevalence of the no-reflow phenomenon was higher in the high-PTX3 group.…”

Section: Discussionmentioning

confidence: 55%

Long-term prognostic value of elevated pentraxin 3 in patients undergoing primary angioplasty for ST-elevation myocardial infarction

Akgül

Baycan

Bulut

et al. 2015

Coronary Artery Disease

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Section: Discussionmentioning

confidence: 55%

Long-term prognostic value of elevated pentraxin 3 in patients undergoing primary angioplasty for ST-elevation myocardial infarction

Akgül

Baycan

Bulut

et al. 2015

Coronary Artery Disease

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“…9,27) Furthermore, plasma PTX3 is more closely associated with the angiographic complexity and severity of coronary artery disease than hs-CRP. 28) However, whether systemic PTX3 levels reflect plaque characteristics remains unclear. The present study therefore evaluated the relationship between systemic PTX3 levels and coronary plaque vulnerability assessed by The present study has a number of limitations.…”

Section: Discussionmentioning

confidence: 99%

Plasma Pentraxin3 Level Is Associated With Plaque Vulnerability Assessed by Optical Coherence Tomography in Patients With Coronary Artery Disease

et al. 2016

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SummaryThe role of pentraxin 3 (PTX3) has been implicated in the process of plaque vulnerability. However, few studies have addressed the direct relationship between plaque morphology and plasma PTX3. We evaluated the relationship between coronary vulnerable plaque, assessed by optical coherence tomography (OCT), and plasma PTX3 in patients with coronary artery disease (CAD).OCT was used to determine plaque vulnerability in 51 patients with non-ST segment elevation acute coronary syndrome (NSTE-ACS; n = 17) and stable angina (SA; n = 34). Both highly-sensitive C-reactive protein and systemic plasma PTX3 were measured.Based on the OCT findings, patients were divided into 3 groups; a fibrous plaque (n = 18), thick-cap fibroatheroma (ThCFA) (n = 19), and thin-cap fibroatheroma (TCFA) (n = 14) groups. ThCFA was defined as a lipid-rich plaque (lipid content in ≥ 2 quadrant) covered with ≥ 65 μm thick fibrous cap, and TCFA was that with < 65 μm. There were no differences in patient characteristics between the 3 groups except for the presence of ACS and eicosapentaenoic acid levels. TCFA was more frequently observed with plaque rupture and intraluminal thrombus compared with the other 2 groups. Plasma PTX3 levels were higher in the TCFA group compared with the fibrous plaque and ThCFA groups, and showed weak correlation with cap thickness.Plasma PTX3 level was associated with plaque vulnerability assessed by OCT in patients with CAD. (Int Heart J 2016; 57: 18-24)

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“…Pentraxin-related protein PTX-3 is one of the long pentraxins and, like CRP, is produced and released in the liver as an acute-phase response to proinflammatory cytokines, and also from within the unstable atherosclerotic plaque. 12,13 During the process of atherogenesis, PTX3 is found to be expressed in human vascular smooth muscle cells via atherogenic lipoproteins, 14 and is thought to upregulate tissue factor expression in human endothelial cells 15 and activated monocytes, 16 and to occur extensively in advanced atherosclerotic plaques. The present study showed that PBMC PTX-3 levels were significantly increased in patients with ACS compared with the controls.…”

Section: Discussionmentioning

confidence: 99%

Pentraxin 3, long expression in mononuclear cells of patients with acute coronary syndrome: Correlation with C-reactive protein and matrix metalloproteinase-9 levels

Zhang

Wang

et al. 2014

J Int Med Res

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Objectives: To investigate expression of pentraxin 3, long (PTX3) in patients with acute coronary syndrome (ACS) and its correlation with matrix metalloproteinase-9 (MMP-9) and C-reactive protein (CRP) levels. Methods: Patients with ACS were randomly assigned to the ACS group (subdivided into unstable angina pectoris [UAP] and acute myocardial infarction [AMI]). Healthy participants and patients with stable angina pectoris (SAP) were enrolled as controls. Mononuclear cell PTX3 expression, and serum MMP-9 and CRP levels, were measured by enzyme-linked immunosorbent assay. Results: The ACS group comprised 200 patients (80 in the UAP subgroup; 120 in the AMI subgroup). The control group comprised 130 participants (80 healthy volunteers and 50 patients with SAP). PTX3 expression was significantly higher in the ACS group compared with controls (3.64 AE 0.49 versus 1.85 AE 0.65 ng/ml), and significantly higher in the AMI compared with the UAP subgroup (5.44 AE 0.47 versus 3.39 AE 0.59 ng/ml). Serum MMP-9 and CRP levels were significantly higher in the ACS group compared with controls (48.55 AE 14.22 versus 23.14 AE 0.62 ng/ml; 4.88 AE 1.76 versus 1.26 AE 0.19 ng/ml, respectively), and significantly higher in the AMI compared with the UAP subgroup (58.13 AE 7.24 versus 31.77 AE 3.61 ng/ml; 5.80 AE 1.46 versus 3.27 AE 0.83 ng/ ml, respectively). PTX3 expression, and MMP-9 and CRP levels in the SAP subgroup, were not significantly different from the healthy participants. PTX3 expression positively correlated with MMP-9 and CRP levels. Conclusions: In patients with ACS, peripheral blood mononuclear cell PTX3 expression, and serum MMP-9 and CRP levels, were significantly enhanced compared with controls; in addition, PTX3 expression positively correlated with MMP-9 and CRP levels. PTX3 may be involved in ACS pathogenesis.

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Serum Pentraxin 3 Levels are Associated with the Complexity and Severity of Coronary Artery Disease in Patients with Stable Angina Pectoris

Abstract: Pentraxin 3, a novel inflammatory marker, was more tightly associated with the complexity and severity of CAD than hs-CRP and was found to be an independent predictor for high SYNTAX score.

Cited by 38 publications

References 36 publications

Long-term prognostic value of elevated pentraxin 3 in patients undergoing primary angioplasty for ST-elevation myocardial infarction

Long-term prognostic value of elevated pentraxin 3 in patients undergoing primary angioplasty for ST-elevation myocardial infarction

Plasma Pentraxin3 Level Is Associated With Plaque Vulnerability Assessed by Optical Coherence Tomography in Patients With Coronary Artery Disease

Pentraxin 3, long expression in mononuclear cells of patients with acute coronary syndrome: Correlation with C-reactive protein and matrix metalloproteinase-9 levels

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