The mean hearing thresholds for this group of aviation personnel are higher than International Standard ISO-7129 would predict according to age. Highly significant changes in hearing threshold after age correction, indicating possible noise-induced hearing loss, were found in all groups at 4 kHz. The fact that helicopter pilots had similar hearing loss to their other aviation colleagues indicates that current hearing protection for these pilots is effective in counteracting the increased noise levels in helicopters.
SUMMARY Enzyme activities in homogenates of the large intestine were measured in biopsies from 11 tubular adenomas and six carcinomas and from the corresponding normal mucosa of each individual. A similar and significant increase was found in the total activities of glucose-6-phosphate dehydrogenase (G 6 PD) Received for publication 14 August 1981 As far as we know enzyme activities have not been measured in homogenates from tubular adenomas of the colon. The present study was carried out in order to see whether the above-mentioned difference in prognosis of tubular adenomas might be apparent from a shift in their enzyme patterns.
MethodsPolyps were removed by sling resection, and biopsies from carcinomas and, for comparison, from normal mucosa were taken during routine colonoscopy. Biopsies from the normal mucosa were always taken more than 5 cm from the tumour. The specimens were quenched. When kept on ice, the polyps were cut, and two pieces from the parietal part of the polyp and samples from the other materials were stored within two hours at -70°C.
Sixty-nine outpatients with endoscopically confirmed duodenal and prepyloric (DU) or gastric ulcers (GU) completed a 4-week double-blind trial with either cimetidine, 1 g/day, or trimipramine, 50 mg/day. Ulcer healing was assessed by endoscopy at 4 weeks. At the end of the study 14 of 23 patients with DU treated with cimetidine and 13 of 25 treated with trimipramine had healed ulcers. In the patients with GU 7 of 11 ulcers (cimetidine) and 4 of 10 (trimipramine) healed. The differences in healing rates between the two treatment groups were not statistically significant, either in DU and GU groups separately or in the total material. The number of pain attacks per week decreased and the symptoms improved significantly in both treatment groups in DU, GU, and totally. Both drugs were well tolerated, but two patients in each treatment group developed a slight increase in serum transaminases. No serious side effects occurred. The study suggests trimipramine as an alternative drug to the well-established drug cimetidine in the treatment of duodenal and possibly also of gastric ulcer.
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