SummaryA novel approach to solid phase extraction, based on the use of a highly selective molecularly imprinted polymer, is presented. The versatility of this type of sorbent for solid phase extraction was demonstrated in a model batch-wise pre-concentration of sameridine prior to gas chromatography. Problems associated with leakage of remaining imprint molecules during the desorption phase could be eliminated by the use of a close structural analogue of sameridine as the imprint species. It was found that a major benefit of the imprinted polymer was its specificity, which lead to distinctly cleaner chromatographic traces and ability to improve sensitivity by extracting sameridine from larger sample volumes.

This consensus statement reflects the deliberations of an international group of stakeholders with a range of expertise in public involvement and engagement (PI&E) relating to data-intensive health research. It sets out eight key principles to establish a secure role for PI&E in and with the research community internationally and ensure best practice in its execution. Our aim is to promote culture change and societal benefits through ensuring a socially responsible trajectory for innovations in this field. Our key premise is that the public should not be characterised as a problem to be overcome but a key part of the solution to establish socially beneficial data-intensive health research for all.

round the world, specialized research centres have developed expertise related to the linkage and analysis of population-wide administrative health data. 1 Canadian examples include ICES in Ontario, 2 the Manitoba Centre for Health Policy, 3 Population Data BC 4 and the Canadian Institute for Health Information. 5 These organizations all work with data sets that are created by linking person-level data from different data sets (e.g., prescription drugs, hospital admissions, mortality) then removing or coding identifying information so that research and analyses can be performed while protecting privacy. Recent high-profile reports and initiatives 6-8 highlight the potential benefits that could be realized by increasing linkage of, and access to, Canadian health data from these centres and other sites. At the same time, substantial public debate has been generated about questionable practices related to health data, including concerns about private sector access to data under care.data in the United Kingdom 9 and concerns about privacy and patient consent for My Health Record in Australia. 10 As stewards of health data that cover the entire population, it is the responsibility of organizations like ICES to engage with the public when considering expanded uses of, and access to, population-wide health data holdings. A social licence to operate is an informal agreement that is granted by communities and relevant stakeholders to an organization to do certain work. 11 Organizations holding a social licence may not even recognize that they have one until it is withdrawn. 11 In their analysis of negative public reaction to care.data in the UK, Carter and colleagues note that "the concept of a social licence describes how the expectations of society regarding some activities may go beyond compliance with the requirements of formal regulation; those who do not fulfil the conditions for the social licence (even if formally compliant) may experience ongoing challenge and contestation." 9 This