Two-dimensional
(2D) MXenes have demonstrated outstanding antimicrobial
properties owing to their unique physiochemical properties and ultrathin
lamellar structure. However, the relationship between MXene sheet
size and its antimicrobial activity and how the atomic structure can
impact the antibacterial mechanism are yet to be revealed. This study
investigates the effect of atomic structure and size dependency on
the antibacterial activity of two niobium carbide MXenes (Nb2CT
x
and Nb4C3T
x
) using model Gram-negative and Gram-positive
bacteria. The results showed that the bactericidal property of Nb2CT
x
and Nb4C3T
x
against Escherichia
coli and Staphylococcus aureus is dependent on the sheet size and atomic structure of both MXenes.
120 μg/mL delaminated (DL)-Nb2CT
x
and DL-Nb4C3T
x
exhibited growth inhibition of 94.2 and 96.1% for E. coli and 91.6 and 93.7% for S.
aureus cells within 3 h of incubation, respectively.
The bacterial cell viability decreased with decreasing lateral sheet
size of DL-Nb2CT
x
and DL-Nb4C3T
x
down to 160 and
183 nm, respectively. DL-Nb4C3T
x
-183 showed higher antibacterial activity than DL-Nb2CT
x
-160 because of a higher c lattice parameter. Moreover, DL-Nb4C3T
x
-183 demonstrated higher oxidative
stress on both bacterial cells in comparison with DL-Nb2CT
x
-160. This study highlights the role
of the atomic structure of MXenes and the importance of tailoring
the lateral size of the nanosheets to optimize the bactericidal properties
of 2D nanomaterials.
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