The detection of high S100B levels in peripheral circulation after acute ischemic stroke and the correlations of S100B levels with infarct size (good) and disability (poor) imply that S100B protein may be used as a peripheral marker in acute ischemic stroke patients.
Özürlülüğün tanımı ve özürlülere sağlık kurulu raporlarının nasıl verilmesi gerektiği ile ilgili mevzuat, Bakanlar Kurulu'nun 16.12.2010 tarih ve 27787 sayılı resmi gazetede yayımlanan "Özürlülük ölçütü, sınıflandırması ve özürlülere verilecek sağlık kurulu raporları hakkında yönetmelik" ile düzenlenmiştir. Özürlü; doğuştan veya sonradan, bedensel, zihinsel, ruhsal, duygusal ve sosyal yeteneklerini çeşitli derecelerde kaybetmesi nedeniyle toplumsal yaşama uyum sağlama ve günlük gereksinimlerini karşılamada güçlükleri olan, korunma, bakım, rehabilitasyon, danışmanlık veya destek hizmetlerine ihtiyaç duyan birey olarak tanımlanır (1). Özürlülük sağlık kurulu üyeleri; iç hastalıkları, genel cerrahi, göz hastalıkları, kulak-burun-boğaz, nöroloji, psikiyatri, fizik tedavi ve rehabilitasyon uzmanlarından oluşur. Özürlü sağlık kurulu raporu; kişilerin özür ve sağlık durumunu, yararlanabileceği sosyal hakları ve çalıştırılamayacağı iş alanlarını belirten belgedir. Özürlü sağlık kurulu raporlarını düzenlemeye yetkili sağlık kurumları ve hakem hastaneleri Sağlık Bakanlığı tarafından belirlenir ve ilan edilir.
Conventional transacetabular removal of the migrated acetabular cup can be hazardous due to intraoperative injury to iliac vessels. We present a case of a migrated acetabular cup, in which we used a combined preperitoneal and acetabular approach for its removal. With a bimanual approach, the procedure was safer and easier and allowed mesh repair of the pelvic bone defect. The preperitoneal mesh repair is a well-known method for inguinofemoral hernias. However, it has not been used before in the repair of an acetabular defect after removal of a migrated cup.
Background/aim: Ganglioside antibodies are identified not only in patients with inflammatory neuropathies but also several central nervous system disorders and paraneoplastic neuropathies. Our aim was to investigate whether ganglioside antibodies are found in autoimmune encephalitis patients and may function as a diagnostic and prognostic biomarker.Materials and methods: Sera and cerebrospinal fluid (CSF) samples of 33 patients fulfilling the criteria for probable autoimmune encephalitis were collected within the first week of clinical manifestation. None of the patients had evident symptoms and findings of peripheral polyneuropathy. Well-characterized anti-neuronal and paraneoplastic antibodies were investigated in sera and CSF and anti-ganglioside (anti-GM1, GM2, GM3, GD1a, GD1b, GT1b and GQ1b) IgG and IgM antibodies were measured in sera using commercial immunoblots.Results: Twenty-eight of 33 autoimmune encephalitis patients displayed antibodies against neuronal surface or onco-neural antigens with N-methyl-D-aspartate receptor (NMDAR), glutamic acid decarboxylase (GAD) and Hu antibodies being the most prevalent. While no anti-ganglioside IgG antibodies were found, 4 patients (2 anti-NMDAR+, 1 anti-GAD+ and 1 antibody negative) with autoimmune limbic encephalitis displayed anti-GM1, anti-GM2, anti-GM3 or anti-GQ1b IgM antibodies. There was no apparent association between anti-ganglioside positivity and clinical and demographic features.
Conclusion:Serum ganglioside IgM antibodies may infrequently emerge during the clinical course of autoimmune limbic encephalitis without evident polyneuropathy.Absence of the IgG response suggests that these antibodies might have developed as a 2 hyperacute immune response to neuro-axonal destruction. Nevertheless, potential impact of ganglioside antibodies on axonal degeneration and neuronal loss in limbic encephalitis pends to be further investigated.
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