There are not many articles about the anatomical knowledge of the variable conditions of the sole of the foot, but normally knowledge of this area is essential for surgeries such as reconstructive or peripheral nerve compression syndrome. In this region, medial plantar nerve (nervus plantaris medialis) innervates the abductor and flexor muscles of the thumb. In addition, there is a region where receives the skin sensation in the foot. When it is damaged or exposed to pressure by any muscle due to an abnormal course, it can't stimulate the relevant muscles and the person may experience numbness and loss of muscle function on the sole of the foot. During a routine cadaver dissection, an abnormal course of nervus plantaris medialis was observed on the left side of a male cadaver. In this case, we presented the abnormal course of some branches of medial plantar nerve and discussed the clinical significance.
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