Objectives
This study aimed to examine the effects of chronic periodontitis and essential hypertension on serum and salivary cartonectin (CTRP3) and procalcitonin (ProCT) levels.
Methods
60 non-smokers were seperated into four groups as; 15 people with essential hypertension (EH) and chronic periodontitis (CP) (HT+ CP+), 15 with EH (HT+ CP-), 15 with CP (HT- CP+), 15 control (HT- CP-). PPD, CAL, PI and GI were measured. All groups had their serum and saliva samples collected. Serum and saliva procalcitonin (ProCT) were measured using an electroluminescence method, and cartonectin (CTRP3) levels were determined by enzyme-linked immunosorbent assay.
Results
When compared to the control group, serum and saliva cartonectin (CTRP3) levels were considerably lower in all groups (respectively p<0.0001, p<0.0001). The serum cartonectin (CTRP3) levels were substantially higher in the HT- CP+ group than in the HT+ CP- group (p=0.002). Serum procalcitonin (ProCT) concentrations were found to be lowest in the HT- CP- group and highest in the HT+ CP+ group. Serum ProCT concentrations did not vary significantly across groups (p=0.110). Salivary procalcitonin (ProCT) levels were below the detection limit in all groups.
Conclusions
When periodontitis coexist with hypertension in individuals, they may have adversely affect each other due to the same sathways in the pathogenesis of these two disorders. So we can suggest that, serum and saliva cartonectin (CTRP3) may play a role during hypertension and periodontal inflammation and represent a novel future therapeutic target.
Periodontal hastalıklar çeşitli mikroorganizmalar tarafından başlatılmış olsa da, kompleks mikroflorası ve konak yanıtı periodontal durumu etkilemekte ve sipesifik hastalık belirteçlerini tanımlamayı zorlaştırmaktadır. Periodontal hastalık tanısında kullanılan sondalamada kanama, cep derinliği, klinik ataçman seviyesi ve radyolojik kemik miktarı gibi klinik periodontal parametreler, hastalığın şiddetinin, prognozunun ve tedaviye verilen yanıtın değerlendirilmesinde yetersiz kalmaktadır. Bu nedenle, dişeti oluğu sıvısı, tükürük ve serum öneklerinde tespit edilebilen çeşitli biyobelirteçler bu konuda bize umut ışığı olmaktadır. Son dönemlerde, doku savunma hücreleri olan adipositlerden salınan ve adipokinler olarak adlandırılan bazı proteinler rapor edilmiştir. Bu derlemede, çeşitli periodontal hastalıklarda çalışılmış adipokinler incelenmiş ve gelecekte adipokinlerin bir biyobelirteç olarak periodontoloji alanında uygulanabilirliği tartışılmıştır.
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