Study design and patientsPatients aged 16 years and older who were diagnosed with brucellosis and regularly presented to the outpatient clinic Infectious Diseases of Bitlis Tatvan State Hospital every 2-4 weeks between October 1, 2018, and December 31, 2019, were enrolled in this retrospective and single-center study. All patient data were retrieved from our previous study 7 . The study patients were also divided into two groups to compare relevant variables: the end-of-treatment SAT-positive group (those with persistent SAT positivity) and the end-of-treatment SAT-negative group (those with nonpersistent SAT positivity). Demographic and clinical dataThe epidemiological, clinical, and laboratory findings of the patients were retrospectively evaluated. Brucellosis was diagnosed with a SAT titer of ≥1/160 or by isolation of Brucella spp. in a blood culture. Clinical improvement was noted in patients who received regular and appropriate treatment for at least 6 weeks and had improved symptoms and signs. A SAT titer of <1/40 at the end of the treatment was accepted as SAT negativity (serological cure), while a titer between 1/40 and 1/160 was considered a low titer. Patients who developed clinical symptoms within 6 months of the treatment and had at least a twofold increase in SAT titers or growth of Brucella spp. in blood culture were considered relapses.
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