Objectives To investigate impacts that effect entrance to intensive care unit, mortality, and cost; according to demographical and clinical parameters of patients, and different anesthetic techniques performed on patients who underwent TUR-P operation. Methods Data of 234 patients aged 60 years and older who underwent TUR-P operations was evaluated retrospectively. The patients were examined in two groups as neuroaxial and general anesthesia groups. Charlson Comorbidity Index, preoperative laboratory parameters, presence of comorbidity, preoperative intensive care requirement, operation duration were obtained from hospital records. The cost calculation was based on the length of the patient's stay in hospital and intensive care unit. Results According to ASA score, no significant difference was observed among operation duration, length of hospital stay and intensive care unit stay. According to the CCI score, there was no significant difference among the operation time; however, when the patient's CCI was 3 and above 3, the duration of intensive care stay and hospital stay were significantly longer. The cost was increased significantly when CCI was 3 and above 3, but did not change according to the ASA score. Conclusions In our study, it was observed that the type of anesthesia did not affect the duration of surgery, rate of entrance to intensive care unit, length of intensive care stay, length of hospital stay, mortality and the cost. However, it was observed that the duration of hospitalization and rate of intensive care unit entrance increased in patients with CCI 3 and above, therefore the cost was increased.