Pirfenidone has a beneficial effect on morphological changes in anti-GBM GN comparable with candesartan although with a trend to slightly better results with candesartan treatment. Moreover, our results suggest an additive effect of combination treatment.

Moritella viscosa-associated winter ulcer affects intensively seafarmed Atlantic salmon (Salmo salar L.) during periods of low water temperature. The clinical presentation varies but often involves prolonged low-grade mortality, with affected fish displaying clearly demarcated lesions on lateral body surfaces, which may in severe cases cover large areas, penetrate deep into underlying muscle tissues and result in terminal septicaemia (Benediktsdóttir et al., 1998;Lunder et al., 1995). The disease is a particular problem in Norwegian aquaculture but also impacts the salmon farming industries of Scotland, Ireland, Iceland, the Faroe Isles and the eastern seaboard of the United States/Canada (Benediktsdóttir