AURELL2, J. CRISTIANSSON3, V. KRIISA-KUNNOS4 and 0. WIEBERT5The suitability of treatment with Ocusert@-P-40, a lamellar system inserted in the eye and allowing the constant release of pilocarpine, was studied in a group of patients (age range 43-83 years) with wide-angle glaucoma. Those patients completing a 3-week trial were included in an 8 month follow-up study in which the long-term efficacy and tolerance of Ocusert" were studied. Treatment was discontinued in 13 of the 42 patients in the 3-week trial owing to initial irritation and retention problems (n= 11) or unsatisfactory control of the intraocular pressure (I.O.P.) (n=2). Of the 29 patients entering the long-term study, two were withdrawn because of tolerance problems and two as a result of unsatisfactory control of I.O.P. The 25 patients completing the study considered the Ocusert" system more convenient and less liable to produce troublesome side-effects than their previous therapy. Ocusert" was best tolerated by the younger patients.
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