Since 1986 two West African countries, Benin and Guinea, have been actively reorganizing their peripheral health systems according to strategies subsequently called the “Bamako Initiative”. Two preceding articles described the strategies implemented and the increased effectiveness of primary health care (PHC) witnessed over a period of six years. This article presents an analysis of cost and coverage data from biannual monitoring sessions between 1988 and 1993 in approximately 200 health centres in Benin and 214 in Guinea. In order to assess affordability, the total and per capita recurrent costs for operational health centres are analysed and then compared. The cost analysis reveals a mean total cost per health centre per year of slightly over US$11,000 in Benin and nearly US$9,000 in Guinea. The median cost per capita per year is approximately US$1.0 in Benin and between US$0.60 and US$0.80 in Guinea. Comparisons of these costs between regions, health centres and over time (as coverage levels evolved) show very little variation in either country. Cost‐effectiveness is estimated by allocating these costs to immunization, antenatal and curative care and comparing them to the coverage achieved with these interventions. First, the cost‐effectiveness of the Bamako Initiative (BI) system as a whole is analysed. The cost per fully vaccinated child is calculated at US$10.9 in Benin and US$8.8 in Guinea. The cost per woman receiving at least three antenatal visits is US$7 in Benin and US$4.7 in Guinea. For curative care, cost per full treatment is US$1.6 in Benin and half this amount in Guinea. Cost‐effectiveness is variable between regions, health centres and over time. An analysis of the characteristics of the most and least cost‐effective centres reveals that these differences in cost‐effectiveness are mainly caused by the coverage levels achieved, since total costs are relatively stable. Finally the efficiency of drug management and prescriptions as well as of outreach for the expanded programme of immunizations (EPI) is estimated by relating specific drug and outreach costs to the number of beneficiaries. The average cost of drugs per treatment is around US$0.5 in Benin and around US$0.3 in Guinea. Cost analysis of outreach activities undertaken for EPI in Guinea revealed a similar average cost per child completely vaccinated for health centres with different intensities of outreach (approximately US$10) and an additional cost per child vaccinated attributable to outreach of US$1–2. © 1997 by John Wiley & Sons, Ltd.

Curative and preventive care utilization in Bamako Initiative health centres in Guinea and Benin increased significantly. Service based data and household survey results are compared and interpreted to evaluate the equity aspects of the Bamako Initiative programmes in these settings. Improvements in the use of preventive services are shared by the richer and poorer groups of the population. Inequities are more apparent regarding curative care. An important part of the population is not using Bamako Initiative Health Centres for financial reasons. However, the poor were found to use these Health Centres relatively more than richer socio‐economic groups. Challenges of the future are identified and recommendations made as to how to tackle the problem of true indigence. © 1997 by John Wiley & Sons, Ltd.

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Redox-polymer nanoparticles are a promising solution to avoid the detrimental dissolution of organic electrode materials while showing discrete redox processes. In this work, catechol-based redox-active polymer nanoparticles (cRPNs) were synthesized through one-step emulsion polymerization with a tunable size from 25 to 150 nm. The fresh cRPNs were characterized and showed a reversible redox process centered at 0.50 V (vs. Ag/ AgCl) in 1 M H 2 SO 4 . Unexpectedly, the cRPN latex aged after days passing from white to pink. This aging resulted in a shift of its redox potential toward higher values, which could be associated to autoxidation of the catechol groups and subsequent crosslinking of NPs due to catechol dimer formation. Finally, we compared the performance of fresh and aged cRPNs in a hybrid supercapacitor device, proving how the aging effect had some benefits such as an increase in the voltage output, specific capacitance, cyclability and Coulombic efficiencies of the device.

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Zika virus (ZIKV) is a widespread mosquito-borne pathogen. Phylogenetically, two lineages of the ZIKV are distinguished: African and Asian-American. The latter became the cause of the 2015-2016 pandemic with severe defeat to newborns. In West African countries the African lineage has been found, but there is evidence of the emergence of Asian-American lineage in Cape Verde and Angola. This highlights the need not only to monitor the ZIKV, but also to sequence the isolates. In this article, we present a case report of Zika fever in a pregnant woman from Guinea, identified in 2018. Viral RNA was detected by qRT-PCR in serum sample. In addition, seroconversion of anti-Zika IgM and IgG antibodies was detected in repeated blood samples. Subsequently, the virus was isolated in C6/36 cell line. The detected ZIKV belonged to the African lineage, the Nigerian sublineage. The strains with the closest sequences were isolated from mosquitoes in Senegal in 2011 and 2015. In addition, we conducted serological screening of 116 blood samples collected from patients presenting to the hospital of Faranah with fevers during the period 2018-2021. As a result, it was found that IgM-positive patients occurred each year, seroprevalence varied between 5.6% and 17.1%.

The Zika virus (ZIKV) is a widespread mosquito-borne pathogen. Phylogenetically, two lineages of ZIKV are distinguished: African and Asian–American. The latter became the cause of the 2015–2016 pandemic, with severe consequences for newborns. In West African countries, the African lineage was found, but there is evidence of the emergence of the Asian–American lineage in Cape Verde and Angola. This highlights the need to not only monitor ZIKV but also sequence the isolates. In this article, we present a case report of Zika fever in a pregnant woman from Guinea identified in 2018. Viral RNA was detected through qRT-PCR in a serum sample. In addition, the seroconversion of anti-Zika IgM and IgG antibodies was detected in repeated blood samples. Subsequently, the virus was isolated from the C6/36 cell line. The detected ZIKV belonged to the African lineage, the Nigerian sublineage. The strains with the closest sequences were isolated from mosquitoes in Senegal in 2011 and 2015. In addition, we conducted the serological screening of 116 blood samples collected from patients presenting to the hospital of Faranah with fevers during the period 2018–2021. As a result, it was found that IgM-positive patients were identified each year and that the seroprevalence varied between 5.6% and 17.1%.