Serum CA19-9 levels were measured in 60 diabetic patients and 40 healthy volunteers. Serum CA19-9 concentration was correlated with hemoglobin Al (HbAl) (r=0.4368 P<0.005) and fasting plasma glucose levels (r=0.3410 P<0.01). None of the 40 healthy subjects showed elevated CA19-9 concentrations over 37 units/ml as the upper normal value. The percentage of positive serum CA19-9 levels in poorly controlled patients (fasting plasma glucose > 200 mg/dl or HbAl>13%) and moderately to well controlled patients was 50%and 10%, respectively. No correlation was found between the level of CA19-9and those total cholesterol, and triglycerides, or the duration of diabetes. In patients who had diabetic retinopathy or persistent proteinuria, the CA19-9concentration was significantly elevated when compared with those without these complications. It has been shown that patients with adenocarcinoma of the gastrointestinal tract have high plasma CA19-9 levels and those who have benign disease have normal CA19-9levels. Even though diabetes mellitus is not a malignant disease, serum CA19-9levels were increased in diabetic patients. These results indicate that HbAl and fasting plasma glucose should be examined in patients with high CA19-9 levels.

No abstract

Summary. The modified sulfide-silver method was applied to the electron microscopic histochemistry of heavy metals (zinc) in the islet cells from normal rabbits, using glutaraldehyde saturated with hydrogen sulfide as a vital fixative. Zinc was distinctly localized at the cores of granules in B cells in various amounts. Secretory granules in A cells sometimes revealed a small amount of zinc, whereas other ultrastructures of both A and B cells did not show any positive reaction. The procedure described in the paper was thought to be useful enough for pursuing nob only the localization but also the dynamics of zinc in pancreatic islets. Histochimie microscopique dlectronique des m~taux lourds dans les ilots de Langerhans de lapinsRdsumd. La mdthode an sulfure d'argent modifide a dtd appliqude ~ l'histochimie microseopique @lectronique des m@taux lourds (zinc) duns les cellules insulaires de lapins normaux en utilisan~ eomme fixateur vital la glutaraldghyde saturde avec du sulfure d'hydrog~ne. Le zinc a dtd localis6 distinctement duns les centres et les membranes limitant les granules dans les cellules B, en quantit@ variables. Les granules sdcr6toires darts les cellules A contenaient parfois une petite quantitd de zinc, tandis que les autres ultrastructures des eellules Aet B ne morttr@renb pus de rdaction positive. Le proc@d@ d6crit duns cet article a 6t6 jugd utile pour rechercher non seulement la localisation du zinc mais aussi sa dynamique duns les riots panerdatiques.

No abstract

No abstract