Beyond Fifth Generation (B5G) networks are expected to be the most efficient cellular wireless networks with greater capacity, lower latency, and higher speed than the current networks. Key enabling technologies, such as millimeter-wave (mm-wave), beamforming, Massive Multiple-Input Multiple-Output (M-MIMO), Device-to-Device (D2D), Relay Node (RN), and Heterogeneous Networks (HetNets) are essential to enable the new network to keep growing. In the forthcoming wireless networks with massive random deployment, frequency re-use strategies and multiple low power nodes, severe interference issues will impact the system. Consequently, interference management represents the main challenge for future wireless networks, commonly referred to as B5G. This paper provides an overview of the interference issues relating to the B5G networks from the perspective of HetNets, D2D, Ultra-Dense Networks (UDNs), and Unmanned Aerial Vehicles (UAVs). Furthermore, the existing interference mitigation techniques are discussed by reviewing the latest relevant studies with a focus on their methods, advantages, limitations, and future directions. Moreover, the open issues and future directions to reduce the effects of interference are also presented. The findings of this work can act as a guide to better understand the current and developing methodologies to mitigate the interference issues in B5G networks.