The world animal protein consumption is increasing each year and it is estimated that annual fishery consumption will be 40 kg per capita in 2030, while it was 19.8 kg in 2013 (FAO, 2020). Based on this projection, especially after 2050, roughly 60% of animal protein need will most likely be met up by fishery products (FAO, 2017). Since production from capture fisheries is limited, aquaculture is expected to get importance more than ever.Aquaculture growth rate is elevated every year due to the introduction of new technologies (Bilen et al., 2013). However, there are some limiting factors in aquaculture, such as stress, diseases, feed supply, environmental pressure and ethics concerning animal welfare (Sönmez, 2017;Taştan & Salem, 2021;Vallejos-Vidal et al., 2016). In aquaculture systems, fish are invariably exposed to stress due to sudden temperature changes in water or handling for various purposes, such as vaccination, transportation and spawning induction (Naylor et al., 2000;Özçelik et al., 2020).There are various methods to prevent or treat diseases, such as vaccination, antibiotic treatment or use of other chemical agents (Corum et al., 2020;Salem et al., 2021;Terzi et al., 2020). Some of these substances have negative effects on the environment, fish health, or even