Introduction: Acne is a chronic relapsing skin condition with multifactorial nature associated with disorders of sebaceous glands activity, psycho-emotional disorders and slow response to treatment.
The aim: To study a pathogenic role of chronic stress and certain metabolic and neuroendocrine disorders in the development of acne in women depending on the duration of the disease.
Materials and methods: A total of 119 women with acne were examined. Index insulin resistance (іndex HOMA), serum cortisol and prolactin, level of Reactivity-Personal
Anxiety and Dermatology Life Quality Index (DLQI) was determined.
Results: Possible changes in serum cortisol level depending on duration of the disease (increased in women with duration of the disease less than 1 year and decreased in
women with duration of the disease 1-5 years), increased index of serum prolactin and HOMA, with more significant changes in women with duration of the disease 1-5 years.
The DLQI was determined in all examined patients. An increased level of anxiety, characterized by higher levels of personal anxiety, was also observed, especially in a group of women with duration of the disease 1-5 years.
Conclusion: The changes in certain neuroendocrine and metabolic indices, which are the markers of chronic stress, worsening of life quality and significant levels of reactivity and personal anxiety, were observed in women with acne. A strong and moderate correlational relationship between the nature of changes in the abovementioned indices and duration of the disease was detected.
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The aim: To determine a possible role of nitric oxide system as one of the pathogenesis links in Stevens-Johnson syndrome depending on the severity of disease progression.
Material and methods: We examined 11 patients with Stevens-Johnson syndrome. The function of nitric oxide system (NO - NOS) in blood serum was examined.
Results: During the study of nitric oxide system (NO-NOS) in patients with SJS, it was observed that NO2¯ level was increased by 1.53 times, NO3¯ level – by 3.33 times, activity of total NOS – by 5.78 times, constitutive (cNOS) – by 1.81 times and inducible (iNOS) – by 13.36 times.
Conclusions: The intensity of nitric oxide system function was studied in patients with Stevens-Johnson syndrome and dependence of changes of its parameters from the clinical signs of disease was detected. It was found that the determination of nitrite and nitrate anion levels in blood serum can be used for the purpose of predicting the disease course and choosing the therapy methods for the patients with SJS.
The aim: Is to increase effectiveness and assess safety of the antiviral therapy in complex treatment of patients with psoriasis with activated chronic herpes virus infection of types 1 and 2.
Matherials and methods: 120 patients and 25 practically healthy persons were examined.
Results: It has been studied an effect of antiviral therapy on the background of basic therapy in patients with P+HSV 1,2: the percentage of HSV 1,2 DNA detection after the use of acyclovir and/or inosine pranobex was decreased in saliva from 22.0±3.43 % to 6.7±1.32 % (р<0.01) and in epithelium – from 33.3±4.23 % to 6.7±1.8 % (р<0.01); The use of antiviral therapy has showed a decrease in the expression of miR 155 molecules from 126.3 ±10.5 U/6 to 62.4±5.48 U/6 (р<0.05), an increase in the number of T-regulatory lymphocytes from 6.8±1.25% to 9.1±1.41% (p=0.0503); a decrease of IFN-α level in saliva from10.1±1.84 ng/ml to 8.2±1.27 ng/ml (р1=0.0398); in the serum IL-23 level was significantly decreased from14.9±2.11 pg/ml to 8.8±2.03 pg/ml (р<0.05) and TGF-β synthesis was increased from 3.9±1.23 pg/ml to 9.3±2.21 pg/ml (р<0.01).
Conclusions: An improved method of treatment and evaluation of its clinical and immunological effectiveness based on an integral criterion was suggested as a result of conducted antiviral therapy amid basic therapy in patients with psoriasis with activated HSV-1 and HSV-2.
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