Magic mushrooms: The investigation of an edible Boletopsis mushroom that is used traditionally in Papua New Guinea as treatment for gastrointestinal complaints led to the discovery of two new heterocyclic p‐terphenyl ethers, boletopsin (1) and 12 (2), along with the known metabolites boletopsin 4 and 7 and cycloleucomelone. Evaluation of the antibiotic activity of the compounds isolated from this Boletopsis sp. supported the traditional medicinal use of the mushroom.
Here we report the discovery and synthesis of complex polybrominated p-terphenyl ethers isolated from a mushroom (Boletopsis sp.) used as a traditional medicine by the Kiovi people in the highlands of Papua New Guinea. Boletopsins 13 and 14 represent the first report of polybrominated fungal metabolites to be produced by a terrestrial fungus. The synthetic method employs 2,4,4,6-tetrabromo-2,5-cyclohexadienone to achieve selective polybromination of the extended aromatic system in a selective and sequential manner.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.