ResumenEl objetivo de este estudio fue determinar el efecto de la harina de hojas de Erythrina sobre los perfiles bioquímicos, parámetros biológicos y tejido hepático de Cavia porcellus. Se utilizaron 75 cuyes machos de 13 días de edad, formándose 5 grupos experimentales con tres repeticiones cada uno. Todos se alimentaron con 100 g/día de King grass y alimento balanceado para cuyes ad libitum. Las hojas con peciolo se secaron y se molturaron a 1 mm de diámetro. La sangre se obtuvo a los 75 días de edad de la vena safena lateral y en suero sanguíneo se determinó perfiles de glucosa, proteína total, albumina, aspartato aminotrasferasa, alanino aminotransferasa, lactato deshidrogenasa y urea. Trozos de hígado se procesaron hasta obtener los cortes histológicos. Los perfiles de proteína total y albumina mostraron regresión lineal positiva (p < 0,05), el rendimiento de carcasa regresión lineal negativa (p < 0,05) y la estructura histológica del hígado no tuvo cambios a medida que incrementó el nivel de harina de Erytrhina en la ración. La Erythrina causó una respuesta contrastante entre los perfiles de proteína total y albumina en sangre y el rendimiento de carcasa y no causó alteración estructural del hígado. Palabras clave: Erythrina; perfiles bioquímicos; parámetros biológicos; tejido hepático. AbstractThe aim of this research was to determine the effect of Erythrine leaves powder on serum biochemical profiles, biological parameters and liver histopathology of Cavia porcellus. 75 thirteen days old male guinea pig distributed in five groups with three replicates each were used. All groups were fed with 100 g/day of king grass and balanced diet ad libitum. Erythrine leaves including petiole were dried, grounded to 1 mm diameter and added to the diet. Blood was obtained from the lateral saphenous vein and in blood serum was measured glucose, total protein, albumin, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase and urea. Liver tissue were processed and stained with hematoxylin and eosin. A positive linear regression in the total protein and albumin (p < 0.05) and a negative linear regression for carcasses (p < 0.05) perfomance and no changes in the liver histologic morphology in relation to the increase of Erythrin leaves flour in the diet were shown. Erythrina caused a contrasting response between total protein and albumin profiles in blood and carcass yield and did not cause structural alteration of the liver.
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