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Background: Neuronal specific Enolase (NSE) is the neuronal form of the glycolytic enzyme enolase. This study has been conducted to see the role of serum NSE in differentiating the side of brain lesion within 24 hours of acute hemorrhagic stroke onset. Methods: The study was conducted in collaboration with the Department of Physiology and Medicine after Ethical clearance from December 2013 to April 2015. Our study group consists of 35 acute hemorrhagic stroke patients (clinically and radio logically confirmed) irrespective of age and sex, admitted in Emergency Unit, Medicine Department within 24 hours of stroke symptom onset. The patients were undergone plain CT scan brain on admission to confirm the diagnosis and the side of the lesion in brain. Serum NSE for these patients was estimated by using NSE Human ELISA Kit, in the Department of Physiology. Results: In this study, serum NSE bears a positive significant correlation to the hematoma volume in brain (r=0.786, p<0.001) and to the National Institute of Health Stroke Scale (NIHSS) (r=0.44, p=0.008). However, there is no significance difference between the serum NSE in right hemispheric brain lesion compared to left hemispheric brain lesion (p=0.597). Conclusions: Serum NSE within 24 hours of stroke onset can reflect the volume of brain lesion and severity of neurological deficit but cannot differentiate the side of brain lesion in these patients.

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Objectives: The aim of this study is to see the role of serum NSE (Neuron Specific Enolase) as a neuronal damage marker and in differentiating the side of brain lesion in acute ischemic stroke patients. Methods: A total of 35 acute ischemic stroke patients (clinically and radiologically confirmed) irrespective of age and sex, admitted in Emergency Unit, Medicine Department within 24 hours of stroke onset were included in this study. Plain CT scan or MRI brain was done for all these patients on admission and after 48 hours to confirm the diagnosis and the side of the lesion in brain. Serum NSE was estimated by using NSE Human ELISA Kit, in the Department of Physiology. Results: In this study, serum NSE bears a positive significant correlation to the infarct volume in brain (r=0.783, p<0.001) and to the National Institute of Health Stroke Scale (NIHSS) (r=0.538, p=0.001). However, there is no significance difference between the serum NSE in right hemispheric brain lesion compared to left hemispheric brain lesion (p=0.596). Conclusions: Serum NSE within 24 hours of stroke onset can reflect the volume of brain lesion and severity of acute stroke but cannot differentiate the side of brain lesion in these patients.

Objectives: To see the risk factors, clinical presentations and radiological profile of acute ischemic stroke in young adults in a tertiary-care hospital of North India. Methods: This study was conducted among 50 acute ischemic stroke patients (clinically and radiologically confirmed) irrespective of sex within the age group of 15-45 years admitted to Department of Medicine (Emergency Unit) after getting clearance from Institutional Ethical Committee (IEC). A proforma for each of the acute ischemic stroke patients was maintained where all clinical information in brief including particulars of the subject, chief complaints, past history, proper general physical examination and systemic examinations etc were recorded. The patients had been undergone plain CT (computed tomography) scan/MRI (Magnetic Resonance Imaging) brain on admission for radiological confirmation and to localize the site of lesion in brain. Results: Hypertension (56%) was the most common risk factor among acute ischemic stroke in young adults, followed by heart disease (54%). Majority of the acute ischemic stroke patients presented with hemiplegia (84%). Beside, imaging findings confirmed left sided brain lesion in majority of the patients (52%) and anterior circulation as the most common territory involved in the brain. Conclusions: Hypertension is very common among the young acute ischemic stroke patients. Most common clinical presentation is hemiplegia. Thus, the knowledge of the risk factors, clinical presentation and radiological findings of acute ischemic stroke in young adults can help in prevention, better understanding and therapeutic decision making in the disease management.