Calcium channel blockers are a group of cardiovascular drugs that used very common in society. Since doctors frequently prescribed them and are easily accessible, it is very common to encounter in the emergency departments with overdose to aim suicide. The overdose of these drugs causes mortality by resistant shock, mortal bradyarrhythmia, cardiogenic shock and multiple organ failure. It is vital to diagnose and treat early. Even though these drugs cause mortality by resistant shock, it can be successfully treatable with effective antidotes and current treatment methods. In this review, we aim to discuss CCBs poisonings widely with current literature.
Purpose: The aim of this study is to provide data about diagnosis, treatment, and results of the patients poisoned by drugs affecting the cardiovascular system. Materials and Methods: Patients aged 18 and over who applied to the emergency department with drug poisoning affecting cardiovasculer system were included in the study. The demographic data, drugs and doses, emergency treatment and the time of development of shock or bradycardia, treatment, antidotes and invasive procedures were recorded. Results: In our study twenty-five patients, 8 (32 %) male and 17 (68 %) female, were included. At the admission, 56 % (n=14) had hypotension, 8 % (n=2) had bradycardia, at the second hour 76 % (n=19) had hypotension, 16 % (n=4) had bradycardia. Within 6 hours after admission, 80 % (n=20) patients had hypotension, 28 % (n=7) patients had bradycardia at least once. Fifty-two percent (n=13) of the patients calcium, 36 % (n=9) glukagon, 32 % (n=8) lipid, 12 % (n=3) atropine, 20 % (n=5) positive inotropes were given. Conclusion: Lipid therapy produces positive results in patients who did not improve with calcium, glucagon and fluid therapy. Patients who received calcium channel blockers experienced more cardiogenic shock and bradycardia was more common in patients receiving beta-blockers.
All over the world, toxic disasters related to methyl alcohol have caused many deaths in the form of occasional epidemics. In our country, cases of methyl alcohol poisoning due to the consumption of illegal beverages, which are made to obtain lowcost drinks from time to time, are encountered with an increasing frequency in emergency services. In the treatment, besides the early emergency admission of the patients, it is very important to distinguish them from the other patients who apply for an ordinary ethyl alcohol intake, in other words, early diagnosis. In addition to these parameters, emergency access to resources such as hemodialysis is the keystone of treatment for the patient to be treated effectively.We aim to discuss the clinical findings and treatment methods of this poisoning, in which early diagnosis and treatment are lifesaving, in the light of current literature.
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