This work is a contribution to cryptography. We have developed a symmetrical blocks ciphering system, that is an improvement of our cryptosystem inspired from genetic algorithm published in AMSE periodical. His complexity is o(n) because all operations used are simple and they are applied randomly in ciphering. Furthermore, in our system the user can choose the size blocks and the length key.
Congenital erythropoietic porphyria (CEP) is a rare genetic disorder leading to accumulation of uro/coproporphyrin-I in tissues due to inhibition of uroporphyrinogen-III synthase. Clinical manifestations of CEP include bone fragility, severe photosensitivity and photomutilation. Currently there is no specific treatment for CEP, except bone marrow transplantation, and there is an unmet need for treating this orphan disease. Fluorescent porphyrins cause protein aggregation, which led us to hypothesize that uroporphyrin-I accumulation leads to protein aggregation and CEP-related bone phenotype. We developed a zebrafish model that phenocopies features of CEP. As in human patients, uroporphyrin-I accumulated in the bones of zebrafish, leading to impaired bone development. Furthermore, in an osteoblast-like cell line, uroporphyrin-I decreased mineralization, aggregated bone matrix proteins, activated endoplasmic reticulum stress and disrupted autophagy. Using high-throughput drug screening, we identified acitretin, a second-generation retinoid, and showed that it reduced uroporphyrin-I accumulation and its deleterious effects on bones. Our findings provide a new CEP experimental model and a potential repurposed therapeutic.
An experiment was performed about the bearing capacity of cold-formed thin-walled steel-OSB composite floor by the sand heap. The strain and deflection response of OSB board and steel beam is analyzed under the load; then the test process is simulated by ANSYS, the results of simulation are agreed with the experiment basically. Through the analysis of experiment and finite element simulation, the results indicate that the composite floor has enough bearing capacity and meets the requirement of the residential building completely.
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