Background: 8-Hydroxyquinoline derivatives are known for their extensive applications in the field of analytical chemistry and separation techniques; their complexes with transition metals also exhibit antibacterial and antifungal activity. Results: In the present study, we synthesized a new series of pyranoquinoline derivatives and evaluated their antibacterial activities. The structures of the synthesized compounds were characterized by Fourier transform infrared (FT-IR), hydrogen-1 nuclear magnetic resonance, carbon-13 nuclear magnetic resonance, and elemental analysis. All the prepared compounds were evaluated in vitro as antimicrobial agents against Gram-positive and Gram-negative bacterial strains (Escherichia coli (ATCC35218), Staphylococcus aureus (ATCC29213), Vibrio parahaemolyticus (ATCC17802), and Pseudomonas aeruginosa (ATCC27853)). The screening test was determined by using the standard protocol of disc diffusion method (DDM). Conclusion: We have synthesized new pyranic compounds bearing an 8-hydroxyquinoline moiety on their structure. The preliminary screening results showed that all the tested compounds have a remarkable inhibitory effect on the growth of the majority of the tested bacterial strains compared to the standard antibiotic (penicillin G), and the chlorinated compound (Q 1) is more active against Gram-positive bacteria than Gram-negative bacteria such as the Staphylococcus aureus strain which is the most sensitive. Gram-positive bacteria are responsible for a wide range of infectious diseases, and rising resistance in this group is causing increasing concern. Thus, this study develops novel heterocyclic compound derivatives of 8-hydroxyquinoline that have demonstrated good antibacterial activity against Gram-positive bacteria.
The purpose of the following study is to evaluate the potential of four bacterial antagonists to reduce the development of the Fusarium dry rot and evaluate their role in growth promotion efficacy (plant height, fresh weight and dry weight) of the potato. After the screening in vitro, four antagonistic strains caused an inhibition of the fungi with a diameter greater than 27 mm, namely Fr43, Fr52, F101 of Pseudomons sp gender, and F31 of Acinetobacter gender. These strains were selected to study their effect in vivo. The treatment of tubers by successive immersions in the spores and in the bacterial suspensions showed the ability of the latter to protect the tubers during the storage. Concerning the growth promotion, all the applied antagonistic isolates exhibit a significant difference compared to the control. Consequently, the Fr43 strain is the most active. It has a height of 110.17cm, a fresh weight of 100,77cm and a dry weight of 44.27cm with a respective correspondence of 52.53%, 60.71 and 25.31% of the test GPE%. For the reduction of the Disease incidence, the isolate Fr43 also demonstrated a significant reduction in the incidence of the disease with 15.3%, which corresponds to a significant effectiveness of biological control of up to 79.92% against Fusarium oxysporum. On the contrary, the isolate F101 has the lowest value of the effectiveness of biological control versus control which can reach only 15.7%. Consequently, the isolates Fr43, Fr52 and F31 have a potential use not only in the bio-protection of potato but also in the integrated management of Fusarium wilt. They are also considered as PGPR.
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