BackgroundPrior studies on Hysterosalpingography (HSG) have shown that pelvic inflammatory disease (PID) related tubal adhesions accounted for 30 – 50% of female infertility, with as high as 80% reported in some studies. With improved access to contraceptives, antibiotics and promotion of safe practices, the abnormal findings in HSG may have reduced or altered.ObjectiveTo document the imaging findings in the HSG of participants and to compare current findings with prior studies done nationally and internationally.MethodA retrospective evaluation of 974 HSGs done at the tertiary diagnostic center over a 7-year period was conducted and analyzed using diagnostic accuracy tables.ResultsTubal pathologies were the most common abnormality in this study, (35.1% of the cases), comprising tubal blockage and hydrosalpinges; followed by uterine masses seen in 223 (22.9%) of the clients. Tubal occlusion was higher in clients with multiple abnormal findings; while normal sized and large uterine cavities had a higher percentage of bilateral tubal patency.ConclusionTubal factors remain the most common abnormality seen in the HSGs of infertile women in this study, though with lower prevalence compared with prior older studies. Forty seven (47%) of the cases of female factor infertility had normal HSGs with bilateral tubal patency.
SUMMARYBackground: Breast cancer is the commonest female cancer in Nigeria. Despite its increased awareness, affordability of available screening tools is a bane. Mammography, the goal standard for screening is costly and not widely available in terms of infrastructure, technical/personnel capabilities. Ultrasound is accessible and affordable. Objectives: This study compared the use of ultrasound and mammography as breast cancer screening tools in women in South West Nigeria by characterizing and comparing the prevalent breast parenchyma, breast cancer features and the independent sensitivity of ultrasound and mammography. Methods: This cross sectional comparative descriptive study used both ultrasound and mammography as screening tools in 300 consenting women aged 30 to 60 years who attended a free breast cancer screening campaign in a tertiary hospital in Lagos. Categorical variables were presented in tables and Chi squares for associations P-value set at ± 0.1. Results: Mean age was 41.01 + 6.5years with majority in the 30 -39 year age group 139 (55%). Fatty (BIRADS A and B) parenchyma predominated {ultrasound 237 (79%); mammography 233 (77.7%)} in all age groups. 7 (2.3%) were confirmed malignant by histology with (6) in the 30-39 age group and (1) in the 40-49 age group. Ultrasound detected all the confirmed cases 7(100%), whereas mammography detected 6 (85%). Sensitivity was higher using ultrasound (100%) than mammography (85.7%). Conclusion: Ultrasound can be utilized as a first line of screening especially in remote/rural areas in developing world.
Sickle cell disease (SCD) and its variants are genetic disorders resulting from the presence of a mutated form of hemoglobin, hemoglobin S (HbS). 1 The prototype of these diseases is sickle cell anemia, an autosomal recessive disorder, which results from point mutation and leads to substitution of valine for glutamic acid, at the sixth position of the beta-globin chain. The resultant hemoglobin molecule has abnormal physiochemical properties that lead to the manifestation of the chronic disease state. 2 SCD affects 20 to 25 million people globally. 3 The exact prevalence is unknown in the United States, 4 but a study by Brousseau et al. 5 on the number of people with SCD in the United States showed 89,079 people in 2005. Prevalence in India varies per tribe from 1% to 40%, with Madhya Pradesh having the highest load with an estimated number of 961,492 heterozygotes and 67,861 homozygotes. 6 In Nigeria, by far the most populous country in sub-Saharan Africa, 24% of the population are carriers of the mutant gene, and the prevalence of sickle cell anemia is 20 per 1000 births. 3 This would indicate that in Nigeria alone, 150,000 children are born with sickle cell anemia every year. 7 The pathophysiology of sickle cell anemia is based on the distortion of red blood cells when these circulate through areas of low oxygen tension. With time, the cells become irreversibly sickled and are either removed from 791157J DMXXX10.
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