ferent time intervals aliquots (4 ml) were withdrawn (under argon) and the resin separated immediately by suction filtration, washed thoroughly with DMF, CH2CI2, and MeOH, and then subjected to amino acid analysis. The rate of decrease in amino acid content was taken as the rate of photolysis of the -methylphenacyl ester anchoring bond. Exactly the same experiments were performed on tetrapeptide resins VII and VIII to determine the rate of photolytic cleavage of the o-nitrobenzyl and benzyl ester linkages. The results are summarized in Figure 1. For the studies of the rates of acidolysis or hydrazinolysis of the resins III, VII, and VIII, 0.5 g each of the samples were stirred individually in 20 volumes each of TFA-CH2CI2 (1:1) or 10% H2NNH2 (DMF) in six separate flasks. Aliquots (1 ml) from each reaction were taken at different times and treated as described above for the photolysis experiments. The results are also shown in Figure 1.
Acid catalyzed reaction of cyelododecane‐1,2‐dione VI with dimethyl,3‐ketoglutarate II led to the formation of methyl (E)‐6,7,8,9,10,11,12,13‐octahydro‐3‐(methoxycarbonyl)cyclododeca‐[b]furan‐2‐aeetate IX, presumably formed through the dihydrodihydroxy furan VIII. This dihydrofuran intermediate VIII was shown to be characteristic of the reaction of 2‐substituted carbonyl‐compounds with 11 for both α‐chlorocyclohexanone and α‐chlorocyclopentanone furnished furans XVIa and XX, respectively, when treated with 11. The effect of dihydrodihydroxy‐furan intermediates on the course of such reactions is discussed.
Project SCHOLAR (Statistical Consulting Help for Organizational Leaders and Academic Researchers) is an undergraduate student statistical consulting service at the University of Central Oklahoma. SCHOLAR students work under the supervision of faculty mentors from the Department of Mathematics and Statistics on various projects submitted from researchers on campus as well as off campus. This year, a SCHOLAR group was asked by the Oklahoma City Metro Literacy Coalition to update estimates of literacy levels in the Oklahoma City (OKC) Metropolitan Area and find factors related to below basic literacy proficiency. The group started by organizing and cleaning the data. Explanatory variables were collected from the 2010 US Census, and were used to develop a model for predicting the 2003 State Assessment of Adult Literacy estimates. The group performed a univariate analysis for each explanatory variable, using the p-value, residual plots, and QQ-plots to determine which variables were significantly related to literacy. The group performed multiple regression with stepwise selection, using all of the explanatory variables resulting from the univariate analysis after eliminating variables due to collinearity. The group intends to use the model along with the 2015 American Community Survey data to compute updated literacy estimates for every zip code in the OKC metro. The software used to perform this research is SAS and R.
Das Diketon (I) kondensiert mit Keto‐glutarsäureester (II) über (III) zu (IV), aus dem die Reduktionsprodukte (Va) und (Vb) bzw. sauer ein Decarboxylierungsprodukt (VI) entsteht.
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