No scientifi c worker has a fi xed level of signifi cance at which from year to year, and in all circumstances, he rejects hypotheses; he rather gives his mind to each particular case in the light of his evidence and his ideas. (Ronald A. Fisher, 1956, p. 42) It is tempting, if the only tool you have is a hammer, to treat everything as if it were a nail.

The results of the present study suggest that the s-allele of the 5HTTLPR and a positive family history of depression are additive risk factors for the development of depression during TD.

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